通过在具有血红素受体表达的新菌株中嵌入血红素,稳定模块化纳米转运体。

Stabilization of Modular Nanotransporters by Embedding Hemin in Them in a New Strain with Heme Receptor Expression.

机构信息

Institute of Gene Biology, Russian Academy of Sciences, Moscow, Russia.

Moscow State University, Moscow, Russia.

出版信息

Dokl Biochem Biophys. 2020 Jan;490(1):47-49. doi: 10.1134/S1607672920010093. Epub 2020 Apr 27.

Abstract

It was found that the use of a new strain-producer Escherichia coli, expressing the heme receptor ChuA, enables obtaining a hemin-containing modular nanotransporter (MNT) for drug delivery into the nuclei of target cells. The hemin-containing MNT becomes stabilized, which leads to an increase in its thermal stability and prevents aggregation of this protein.

摘要

研究发现,使用表达血红素受体 ChuA 的新型产菌株大肠杆菌,可以获得含有血红素的模块化纳米转运体(MNT),用于将药物递送到靶细胞的细胞核内。含有血红素的 MNT 变得稳定,从而提高了其热稳定性并防止了这种蛋白质的聚集。

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