Dept. of Neurology, University of Würzburg, 97080, Würzburg, Germany.
Dept. of Neurology, University of Würzburg, 97080, Würzburg, Germany.
Parkinsonism Relat Disord. 2020 Sep;78:100-104. doi: 10.1016/j.parkreldis.2020.07.016. Epub 2020 Jul 31.
The feeling of body ownership relies on the binding of multisensory body-related signals. Various sensory abnormalities have been described in Parkinson's disease (PD).
To assess the rubber hand illusion (RHI) in patients with PD (PwPD) and age-matched healthy controls (CTRL). To evaluate the influence of the dopaminergic system in a PwPD subgroup OFF medication.
The RHI paradigm was applied to 42 PwPD and 48 CTRL. In this experimental setup, stroking a visible plastic hand simultaneously with the covered real hand elicits the feeling of ownership over the seen hand. Asynchronous stroking served as a control condition. Proprioceptive bias and an illusion score based on a questionnaire were used as measures of the RHI. Seventeen PwPD additionally underwent the experiments "OFF medication".
Compared to CTRL, PwPD showed higher proprioceptive bias independent of the stroking condition (p = 0.015), and had higher illusion scores in the asynchronous condition (p < 0.05). In PwPD, there were no significant differences between ON- and OFF-medication state.
In PwPD, responses to the RHI are less specific with respect to the degree of synchronicity of brushstrokes. This might be attributed to a less stable body representation, internal "noise" during multisensory integration, or a blur of temporal discrimination in PD. The fact that RHI measures did not differ between ON- and OFF-medication states indicates an involvement of non-dopaminergic transmitter systems in this finding.
躯体所有权的感觉依赖于多感觉与身体相关的信号的绑定。帕金森病（PD）患者已经描述了各种感觉异常。
评估帕金森病患者（PwPD）和年龄匹配的健康对照组（CTRL）的橡胶手错觉（RHI）。评估多巴胺能系统对 PwPD 亚组停药时的影响。
将 RHI 范式应用于 42 名 PwPD 和 48 名 CTRL。在这个实验设置中，同时刷一个可见的塑料手和被覆盖的真实手会引起对所见手的所有权的感觉。异步刷作为对照条件。基于问卷的本体感受偏差和错觉得分被用作 RHI 的测量。另外，17 名 PwPD 还进行了“停药”实验。
与 CTRL 相比，PwPD 表现出更高的本体感受偏差，与刷动条件无关（p=0.015），并且在异步条件下的错觉得分更高（p<0.05）。在 PwPD 中，ON-和 OFF-药物状态之间没有显著差异。
在 PwPD 中，对 RHI 的反应在刷动的同步性程度上不那么特异。这可能归因于身体表示的稳定性降低，多感觉整合过程中的内部“噪声”，或者 PD 中的时间辨别力模糊。RHI 测量值在 ON-和 OFF-药物状态之间没有差异表明非多巴胺能递质系统参与了这一发现。
