通过溶解动态核极化实现超极化:新技术和新方法进展。

Hyperpolarization via dissolution dynamic nuclear polarization: new technological and methodological advances.

机构信息

Department of Health Technology, Center for Hyperpolarization in Magnetic Resonance, Technical University of Denmark, Building 349, 2800, Kgs Lyngby, Denmark.

Laboratory for Functional and Metabolic Imaging, École Polytechnique Fédérale de Lausanne, Route Cantonale, 1015, Lausanne, Switzerland.

出版信息

MAGMA. 2021 Feb;34(1):5-23. doi: 10.1007/s10334-020-00894-w. Epub 2020 Nov 13.

Abstract

Dissolution-DNP is a method to boost liquid-state NMR sensitivity by several orders of magnitude. The technique consists in hyperpolarizing samples by solid-state dynamic nuclear polarization at low temperature and moderate magnetic field, followed by an instantaneous melting and dilution of the sample happening inside the polarizer. Although the technique is well established and the outstanding signal enhancement paved the way towards many applications precluded to conventional NMR, the race to develop new methods allowing higher throughput, faster and higher polarization, and longer exploitation of the signal is still vivid. In this work, we review the most recent advances on dissolution-DNP methods trying to overcome the original technique's shortcomings. The review describes some of the new approaches in the field, first, in terms of sample formulation and properties, and second, in terms of instrumentation.

摘要

溶解态动态核极化(DNP)是一种将液体状态下的 NMR 灵敏度提高几个数量级的方法。该技术通过在低温和中等磁场下进行固态动态核极化来极化样品,然后在极化器内部瞬间将样品熔化和稀释。尽管该技术已经成熟,并且出色的信号增强为传统 NMR 无法实现的许多应用铺平了道路,但开发允许更高通量、更快和更高极化以及更长时间利用信号的新方法的竞争仍然激烈。在这项工作中,我们回顾了溶解态 DNP 方法的最新进展,试图克服原始技术的缺点。该综述首先从样品配方和性质方面,其次从仪器方面描述了该领域的一些新方法。

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