First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Life Sci. 2021 Feb 15;267:118918. doi: 10.1016/j.lfs.2020.118918. Epub 2020 Dec 19.
The NLRP3 inflammasome regulates innate immune and inflammatory responses by promoting pro-inflammatory cytokines such as IL-18 and IL-1β. NLRP3 is one of the main factors restricting the activation of the inflammasome, which is closely related to the abundance and localization of NLRP3. A substantial number of studies have focused on specifically targeting NLRP3 to develop inhibitors against NLRP3 inflammasome. Here, we succinctly review the regulation of NLRP3 expression at DNA/chromosome, transcriptional, post-transcriptional, and translation levels. These are critical for the fine regulation of the NLRP3 inflammasome.
NLRP3 炎性小体通过促进白细胞介素-18（IL-18）和白细胞介素-1β（IL-1β）等促炎细胞因子的表达来调节先天免疫和炎症反应。NLRP3 是限制炎性小体激活的主要因素之一，其与 NLRP3 的丰度和定位密切相关。大量研究集中于特异性靶向 NLRP3 以开发针对 NLRP3 炎性小体的抑制剂。在这里，我们简要综述了 NLRP3 在 DNA/染色体、转录、转录后和翻译水平的表达调控。这些对 NLRP3 炎性小体的精细调控至关重要。
