Amenta Eva M, Spallone Amy, Rodriguez-Barradas Maria C, El Sahly Hana M, Atmar Robert L, Kulkarni Prathit A
General Internal Medicine, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Infectious Diseases Section, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Open Forum Infect Dis. 2020 Oct 21;7(12):ofaa509. doi: 10.1093/ofid/ofaa509. eCollection 2020 Dec.
As the coronavirus disease 2019 (COVID-19) pandemic has progressed, a large volume of literature has developed delineating the clinical manifestations of acute infection. Recent reports have also started to describe persistent symptoms extending beyond the period of initial illness or hospitalization. Anecdotes of different signs and symptoms occurring after acute infection have also arisen in the lay press. Here we describe the current existing medical literature on the emerging concept of postacute COVID-19 and suggest an approach to classifying different manifestations of the syndrome. We also review long-term clinical manifestations observed in patients who recovered from infection due to other epidemic coronaviruses and briefly discuss potential mechanisms driving the phenomenon of postacute COVID-19.
随着2019冠状病毒病（COVID-19）大流行的发展，大量文献阐述了急性感染的临床表现。近期报告也开始描述在初始疾病或住院期之后仍持续存在的症状。大众媒体中也出现了关于急性感染后出现不同体征和症状的传闻。在此，我们描述了关于急性COVID-19后这一新兴概念的现有医学文献，并提出一种对该综合征不同表现进行分类的方法。我们还回顾了从其他流行性冠状病毒感染中康复的患者所观察到的长期临床表现，并简要讨论了驱动急性COVID-19后现象的潜在机制。
