含木质素基碳点的 pH/温度双重响应水凝胶的简便合成与性能。
Facile synthesis and performance of pH/temperature dual-response hydrogel containing lignin-based carbon dots.
机构信息
College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China.
College of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, China; State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
出版信息
Int J Biol Macromol. 2021 Apr 1;175:516-525. doi: 10.1016/j.ijbiomac.2021.02.049. Epub 2021 Feb 8.
This study demonstrated a facile method to synthesize lignin-based carbon dots (L-CDs) first. Results indicated that the L-CDs had a diameter of 2-5 nm and a graphene-like crystalline structure. It was found that under the optimal synthesis conditions, the fluorescence lifetime of L-CDs was about 12 ns. Within the range of pH 1-10, the fluorescence intensity of the L-CDs and pH value followed a linear relationship. With the contribution of L-CDs, pH/temperature dual responsive hydrogel was synthesized. The elastic modulus G' of hydrogel was much higher than viscous modulus G″. When the PVA content was larger than 10 wt%, the temperature sensitivity and water retention rate gradually decreased. The skeleton of hydrogels had a typical porous honeycomb structure, which made it possible to control its internal pore size by adjusting the content of PVA. There was a linear relationship between the fluorescence intensity of hydrogels and pH value in the range of pH 1-7. Therefore, the pH/temperature dual responsive hydrogel presented a new route for designing tissue engineering scaffolds and drug carriers.
本研究首先展示了一种简便的方法来合成基于木质素的碳点（L-CDs）。结果表明，L-CDs 的直径为 2-5nm，具有类石墨烯的结晶结构。研究发现，在最佳合成条件下，L-CDs 的荧光寿命约为 12ns。在 pH 1-10 的范围内，L-CDs 的荧光强度与 pH 值呈线性关系。在 L-CDs 的贡献下，合成了 pH/温度双重响应水凝胶。水凝胶的弹性模量 G'远高于粘性模量 G″。当 PVA 含量大于 10wt%时，温度敏感性和保水率逐渐降低。水凝胶的骨架具有典型的多孔蜂窝结构，通过调整 PVA 的含量可以控制其内部孔径。在 pH 1-7 的范围内，水凝胶的荧光强度与 pH 值之间存在线性关系。因此，pH/温度双重响应水凝胶为设计组织工程支架和药物载体提供了新途径。
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