Faculty of Science and Engineering, University of Nottingham Malaysia, 43500, Semenyih, Selangor, Malaysia.
China-ASEAN College of Marine Sciences, Xiamen University Malaysia, 43900, Sepang, Selangor, Malaysia.
Pathol Res Pract. 2021 Mar;219:153326. doi: 10.1016/j.prp.2020.153326. Epub 2021 Jan 13.
MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are capable of regulating gene expression post-transcriptionally. Since the past decade, a number of in vitro, in vivo, and clinical studies reported the roles of these non-coding RNAs (ncRNAs) in regulating angiogenesis, an important cancer hallmark that is associated with metastases and poor prognosis. The specific roles of various miRNAs and lncRNAs in regulating angiogenesis in breast cancer, with particular focus on the downstream targets and signalling pathways regulated by these ncRNAs will be discussed in this review. In light of the recent trend in exploiting ncRNAs as cancer therapeutics, the potential use of miRNAs and lncRNAs as biomarkers and novel therapeutic agent against angiogenesis was also discussed.
微小 RNA（miRNA）和长链非编码 RNA（lncRNA）能够在后转录水平上调节基因表达。在过去的十年中，许多体外、体内和临床研究报告了这些非编码 RNA（ncRNA）在调节血管生成中的作用，血管生成是癌症的一个重要标志，与转移和预后不良有关。本综述讨论了各种 miRNA 和 lncRNA 在调节乳腺癌血管生成中的具体作用，特别关注这些 ncRNA 调节的下游靶标和信号通路。鉴于最近利用 ncRNA 作为癌症治疗的趋势，还讨论了 miRNA 和 lncRNA 作为血管生成标志物和新型治疗剂的潜在用途。
