病原体与疾病嗜性的核心规律
Central Rules of Pathogen and Disease Tropism.
作者信息
McCall Laura-Isobel
机构信息
Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK, United States.
Department of Microbiology and Plant Biology, University of Oklahoma, Norman, OK, United States.
出版信息
Front Cell Infect Microbiol. 2021 Feb 25;11:640987. doi: 10.3389/fcimb.2021.640987. eCollection 2021.
Understanding why certain people get sick and die while others recover or never become ill is a fundamental question in biomedical research. A key determinant of this process is pathogen and disease tropism: the locations that become infected (pathogen tropism), and the locations that become damaged (disease tropism). Identifying the factors that regulate tropism is essential to understand disease processes, but also to drive the development of new interventions. This review intersects research from across infectious diseases to define the central mediators of disease and pathogen tropism. This review also highlights methods of study, and translational implications. Overall, tropism is a central but under-appreciated aspect of infection pathogenesis which should be at the forefront when considering the development of new methods of intervention.
理解为什么有些人患病并死亡，而另一些人康复或从未患病，这是生物医学研究中的一个基本问题。这个过程的一个关键决定因素是病原体和疾病嗜性：被感染的部位（病原体嗜性）以及受损的部位（疾病嗜性）。确定调节嗜性的因素对于理解疾病过程至关重要，同时也推动新干预措施的开发。这篇综述融合了传染病领域的研究，以确定疾病和病原体嗜性的核心介质。这篇综述还强调了研究方法及转化意义。总体而言，嗜性是感染发病机制的一个核心但未得到充分重视的方面，在考虑开发新的干预方法时应处于前沿位置。
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