Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
Guangdong Province Key Laboratory of Animal Nutritional Regulation, College of Animal Science, South China Agricultural University, Guangzhou, China.
Front Endocrinol (Lausanne). 2021 Mar 8;12:650284. doi: 10.3389/fendo.2021.650284. eCollection 2021.
The earliest hypoxia-inducible factor (HIF) function was to respond to hypoxia or hypoxic conditions as a transcription factor. Recent studies have expanded our understanding of HIF, and a large amount of evidence indicates that HIF has an essential effect on central regulation of metabolism. The central nervous system's response to glucose, inflammation, and hormones' main influence on systemic metabolism are all regulated by HIF to varying degrees. In the hypothalamus, HIF mostly plays a role in inhibiting energy uptake and promoting energy expenditure, which depends not only on the single effect of HIF or a single part of the hypothalamus. In this paper, we summarize the recent progress in the central regulation of metabolism, describe in detail the role of HIF in various functions of the hypothalamus and related molecular mechanisms, and reveal that HIF is deeply involved in hypothalamic-mediated metabolic regulation.
最早的缺氧诱导因子 (HIF) 功能是作为转录因子对缺氧或低氧条件做出反应。最近的研究扩展了我们对 HIF 的理解，大量证据表明 HIF 对代谢的中枢调节具有重要作用。中枢神经系统对葡萄糖、炎症和激素的反应以及它们对全身代谢的主要影响，都在不同程度上受到 HIF 的调节。在下丘脑中，HIF 主要起到抑制能量摄取和促进能量消耗的作用，这不仅取决于 HIF 的单一作用或下丘脑的单一部位。本文总结了代谢的中枢调节的最新进展，详细描述了 HIF 在下丘脑的各种功能中的作用及其相关的分子机制，并揭示了 HIF 深度参与了下丘脑介导的代谢调节。
