Department of Optometry and Vision Science, School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.
Centre for Ocular Research & Education, School of Optometry & Vision Science, University of Waterloo, Waterloo, Ontario, Canada.
Ocul Surf. 2021 Jul;21:250-256. doi: 10.1016/j.jtos.2021.03.006. Epub 2021 Mar 23.
To evaluate the precorneal tear film (PCTF) and lipid layer (TFLL) thicknesses and thinning rates in meibomian gland dysfunction (MGD) using a combined ultra-high-resolution optical coherence tomography (OCT) and thickness dependent fringe (TDF) interferometry system.
Based on the Tear Film and Ocular Surface Society (TFOS) International Workshop on Meibomian Gland Dysfunction diagnostic algorithm, the Ocular Surface Disease Index (OSDI) and meibum grade score (MGS) were used to classify subjects into four groups: Normal (OSDI<13 and MGS<10), MGD (OSDI≥13 and MGS≥10), Asymptomatic MGD (OSDI<13 and MGS≥10), and Mixed (OSDI≥13 and MGS<10). The OCT/TDF system was used to capture PCTF and TFLL thicknesses and thinning rates. Kruskal-Wallis was used to compare median PCTF and TFLL thicknesses and thinning rates.
There were 190 subjects categorized into four groups: Normal (n = 63), MGD (n = 51), Asymptomatic MGD (n = 29), and Mixed (n = 47). The PCTF was significantly thinner in the Mixed group (3.3 [1.2]) than in the Normal (p < 0.001), MGD (p < 0.001) and Asymptomatic MGD (p = 0.009) groups. Relative to the Normal (4.5 [4.5] μm/min) and Mixed (5.0 [2.0] μm/min) groups, the rate of PCTF thinning was faster in the MGD (8.1 [3.0] μm/min, both p < 0.001) and Asymptomatic MGD (6.9 [3.1] μm/min, p = 0.009 and p = 0.04, respectively) groups. The correlation between PCTF thinning rate and TFLL thickness was ρ = -0.46, p < 0.001.
Symptomatic and asymptomatic MGD shows rapid PCTF thinning rates (evaporation), while the PCTF thickness was reduced in mixed disease. Thicker lipid layers were associated with slower PCTF thinning.
使用联合超高分辨率光相干断层扫描（OCT）和厚度相关条纹（TDF）干涉测量系统评估睑板腺功能障碍（MGD）的泪膜前（PCTF）和脂质层（TFLL）厚度和变薄率。
根据泪膜和眼表面协会（TFOS）关于睑板腺功能障碍诊断算法的国际研讨会，使用眼表疾病指数（OSDI）和睑脂等级评分（MGS）将受试者分为四组：正常（OSDI<13 和 MGS<10）、MGD（OSDI≥13 和 MGS≥10）、无症状 MGD（OSDI<13 和 MGS≥10）和混合（OSDI≥13 和 MGS<10）。OCT/TDF 系统用于捕获 PCTF 和 TFLL 厚度和变薄率。使用 Kruskal-Wallis 比较中位数 PCTF 和 TFLL 厚度和变薄率。
共有 190 名受试者分为四组：正常（n=63）、MGD（n=51）、无症状 MGD（n=29）和混合（n=47）。混合组的 PCTF 明显更薄（3.3[1.2]），明显薄于正常组（p<0.001）、MGD 组（p<0.001）和无症状 MGD 组（p=0.009）。与正常组（4.5[4.5]μm/min）和混合组（5.0[2.0]μm/min）相比，MGD 组（8.1[3.0]μm/min，均 p<0.001）和无症状 MGD 组（6.9[3.1]μm/min，p=0.009 和 p=0.04）的 PCTF 变薄率更快。PCTF 变薄率与 TFLL 厚度之间的相关性为 ρ=-0.46，p<0.001。
有症状和无症状 MGD 表现出快速的 PCTF 变薄率（蒸发），而混合疾病的 PCTF 厚度降低。较厚的脂质层与较慢的 PCTF 变薄相关。
