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不同溶剂所得 L'Hér. 提取物的抗氧化和酶抑制特性评价。

Evaluation of Antioxidant and Enzyme Inhibition Properties of L'Hér. Extracts Obtained with Different Solvents.

机构信息

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via Marzolo 5, 35131 Padova, Italy.

Department of Biology, Science Faculty, Selcuk University, Campus, 42130 Konya, Turkey.

出版信息

Molecules. 2021 Mar 28;26(7):1902. doi: 10.3390/molecules26071902.

DOI:10.3390/molecules26071902
PMID:33800622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038089/
Abstract

L'Hér methanol extract was studied by NMR and two different LC-DAD-MS using electrospray (ESI) and atmospheric pressure chemical ionization (APCI) sources to obtain a quali-quantitative fingerprint. Forty different phytochemicals were identified, and twenty of them were quantified, whereas the main constituents were dihydro α ionol--[arabinosil(1-6) glucoside] (133 mg/g), dihydro β ionol--[arabinosil(1-6) glucoside] (80 mg/g), β-sitosterol (49 mg/g), and isorhamnetin-3--rutinoside (26 mg/g). was extracted with different solvents-namely, water, methanol, dichloromethane, and ethyl acetate-and the extracts were assayed using different in vitro tests. The methanolic extracts presented the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) values. All the tested extracts exhibited inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with a higher activity observed for dichloromethane (AChE: 5.03 and BChE: 16.41 mgGALAE/g), while the methanolic extract showed highest impact against tyrosinase (49.83 mgKAE/g). Taken together, these findings suggest as a novel source of bioactive phytochemicals with potential for commercial development.

摘要

采用核磁共振（NMR）和两种不同的 LC-DAD-MS 方法，使用电喷雾（ESI）和大气压化学电离（APCI）源，对龙舌兰甲醇提取物进行了研究，以获得定性和定量的指纹图谱。鉴定出 40 种不同的植物化学物质，其中 20 种进行了定量分析，而主要成分是二氢α-依兰醇-（阿拉伯糖基（1-6）葡萄糖苷）（133mg/g）、二氢β-依兰醇-（阿拉伯糖基（1-6）葡萄糖苷）（80mg/g）、β-谷甾醇（49mg/g）和异鼠李素-3-O-新橙皮糖苷（26mg/g）。用不同的溶剂（水、甲醇、二氯甲烷和乙酸乙酯）提取 ，并用不同的体外试验对提取物进行了测定。甲醇提取物的 1,1-二苯基-2-苦基肼（DPPH）、2,2'-联氮-双（3-乙基苯并噻唑啉-6-磺酸）（ABTS）和铁还原抗氧化能力（FRAP）值最高。所有测试的提取物均对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）表现出抑制作用，二氯甲烷提取物表现出更高的活性（AChE：5.03 和 BChE：16.41mgGALAE/g），而甲醇提取物对酪氨酸酶的抑制作用最强（49.83mgKAE/g）。综上所述，这些发现表明 是具有商业开发潜力的新型生物活性植物化学物质来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/698b4be25328/molecules-26-01902-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/eaf06d7cbd87/molecules-26-01902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/b3de0da63bc7/molecules-26-01902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/5ff3fbab58e0/molecules-26-01902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/908ae330a875/molecules-26-01902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/4a8c8deabc86/molecules-26-01902-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/02b5f77ee583/molecules-26-01902-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/ea839a233baa/molecules-26-01902-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/f5f8f861d75e/molecules-26-01902-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/698b4be25328/molecules-26-01902-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/eaf06d7cbd87/molecules-26-01902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/b3de0da63bc7/molecules-26-01902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/5ff3fbab58e0/molecules-26-01902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/908ae330a875/molecules-26-01902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/4a8c8deabc86/molecules-26-01902-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/02b5f77ee583/molecules-26-01902-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/ea839a233baa/molecules-26-01902-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/f5f8f861d75e/molecules-26-01902-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d64/8038089/698b4be25328/molecules-26-01902-g009.jpg

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