Laboratory of Mucosal Immunology, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul 03080, Korea.
Mol Cells. 2021 May 31;44(5):301-309. doi: 10.14348/molcells.2021.0053.
Innate lymphoid cells (ILCs) are the most recently discovered family of innate immune cells. ILCs can be categorized into three groups on the basis of the transcription factors that direct their functions and the cytokines they produce. Notably, these functions parallel the effector functions of T lymphocytes. ILCs play a frontline role in host defense and tissue homeostasis by responding rapidly to environmental factors, conducting effector responses in a tissue-specific manner, and interacting with hematopoietic and non-hematopoietic cells throughout the body. Moreover, recent studies reveal that ILCs are involved in development of various inflammatory diseases, such as respiratory diseases, autoimmune diseases, or cancer. In this review, we discuss the recent findings regarding the biology of ILCs in health and inflammatory diseases.
先天淋巴细胞（ILCs）是最近发现的先天免疫细胞家族。根据指导其功能的转录因子和产生的细胞因子，ILCs 可分为三组。值得注意的是，这些功能与 T 淋巴细胞的效应功能相似。ILCs 通过快速响应环境因素，以组织特异性方式进行效应应答，并与全身的造血和非造血细胞相互作用，在宿主防御和组织稳态中发挥前沿作用。此外，最近的研究表明，ILCs 参与了各种炎症性疾病的发展，如呼吸道疾病、自身免疫性疾病或癌症。在这篇综述中，我们讨论了 ILCs 在健康和炎症性疾病中的生物学的最新发现。
