血清弹性蛋白衍生肽与腹膜透析患者腹主动脉钙化的相关性：一项横断面研究。

Association between serum elastin-derived peptides and abdominal aortic calcification in peritoneal dialysis patients: a cross-sectional study.

机构信息

Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Department of Nephrology, Taizhou People's hospital, The Fifth Affiliated Hospital of Nantong University, Taizhou, China.

出版信息

Ren Fail. 2021 Dec;43(1):860-868. doi: 10.1080/0886022X.2021.1918163.

DOI:10.1080/0886022X.2021.1918163

PMID:33993833

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8143601/

Abstract

BACKGROUND

Peritoneal dialysis (PD) patients experience accelerated arterial aging, which is characterized by elastin degradation. Elastin-derived peptides (EDPs) are direct products of elastin fragmentation. This study tried to explore the association between serum EDPs and abdominal aortic calcification (AAC) in PD patients.

METHODS

Serum levels of EDPs were analyzed in 126 eligible PD patients and 30 controls. PD patients were grouped according to the annularity of AAC evaluated by an abdominal computed tomography (CT) scan. Serum EDPs were analyzed in relation to the presence of AAC or severe AAC in PD patients by logistic regression analysis.

RESULTS

Serum EDPs in PD patients were significantly higher than age-matched controls. In 126 PD patients, higher EDPs was associated with greater risk of present AAC (OR = 1.056, 95%CI 1.010-1.103) and severe AAC (OR = 1.062, 95%CI 1.004-1.123). A combination of EDPs substantially improved the accuracy of diagnostic performance for AAC and severe AAC.

CONCLUSIONS

EDPs can predict the presence and extent of AAC in PD patients, indicating its possible role to recognize PD patients at risk for AAC and severe AAC.

摘要

背景

腹膜透析（PD）患者经历动脉老化加速，其特征为弹性蛋白降解。弹性蛋白衍生肽（EDP）是弹性蛋白片段的直接产物。本研究试图探讨 PD 患者血清 EDP 与腹主动脉钙化（AAC）之间的关系。

方法

分析了 126 名符合条件的 PD 患者和 30 名对照者的血清 EDP 水平。根据腹部 CT 扫描评估的 AAC 环状度，将 PD 患者分为两组。通过 logistic 回归分析，研究了血清 EDP 与 PD 患者 AAC 或重度 AAC 的存在之间的关系。

结果

PD 患者的血清 EDP 明显高于年龄匹配的对照组。在 126 名 PD 患者中，较高的 EDP 与存在 AAC 的风险增加相关（OR=1.056，95%CI 1.010-1.103）和重度 AAC（OR=1.062，95%CI 1.004-1.123）。EDP 的联合显著提高了 AAC 和重度 AAC 的诊断性能准确性。