BluePearl Maitland-Internal Medicine, Maitland, Florida, USA.
J Vet Intern Med. 2021 Jul;35(4):1972-1976. doi: 10.1111/jvim.16182. Epub 2021 May 28.
Describe the diagnosis, clinical course, and management of a dog with systemic Mycoleptodiscus indicus infection.
A 5-year-old male neutered Giant Schnauzer presented with left eye anterior uveitis, peripheral lymphadenopathy, hyperglobulinemia, anemia, and thrombocytopenia. A diagnosis of M. indicus infection was made based on histopathology and PCR. Treatment with itraconazole and terbinafine resulted in resolution of the hyperglobulinemia, anemia, thrombocytopenia, and peripheral lymphadenopathy. No evidence of fungal organisms was identified on lymph node, liver, or ocular histopathology after 7 months of treatment.
This case is the first report of a systemic M. indicus infection in an apparently immunocompetent dog. Clinical resolution was achieved with systemic itraconazole and terbinafine.
描述一例患有全身性 Mycoleptodiscus indicus 感染的犬的诊断、临床经过和治疗方法。
一只 5 岁雄性去势巨型雪纳瑞犬因左眼眼前段葡萄膜炎、外周淋巴结病、高球蛋白血症、贫血和血小板减少而就诊。基于组织病理学和 PCR 检查，诊断为 M. indicus 感染。伊曲康唑和特比萘芬联合治疗后，高球蛋白血症、贫血、血小板减少和外周淋巴结病得到缓解。治疗 7 个月后，在淋巴结、肝脏或眼部组织病理学检查中均未发现真菌。
本病例是首例报道的免疫功能正常犬发生全身性 M. indicus 感染。系统性伊曲康唑和特比萘芬联合治疗后获得临床缓解。
