B-vitamins are a class of water-soluble micronutrients that are required for cell metabolism. These include thiamin (vitamin B), riboflavin (vitamin B), niacin (vitamin B), pantothenic acid (vitamin B), pyridoxine (vitamin B), biotin (vitamin B), folate (vitamin B), and vitamin B. B-vitamins serve as cofactors in the metabolism of amino acids, fatty acids, and sugars, as well as the synthesis and methylation of DNA (McCormick et al., ; Powers, ; Kamanna and Kashyap, ; Stover, ; Allen, ; Combs, Jr., 2012). In particular, folate, vitamin B, and vitamin B are required in one-carbon metabolism, including purine biosynthesis and production of -adenosyl methionine, the universal methyl donor required in over 100 methylation processes (Stover, ; Finkelstein et al., 2015). Requirements for B-vitamins are increased during periods of rapid growth and development, including during pregnancy and early childhood (Stover, ; Finkelstein et al., 2015).