Department of Gynecology, Chifeng Municipal Hospital, Chifeng Clinical Medical School of Inner Mongolia Medical University, Chifeng, China.
Department of Tumor Surgery, Chifeng Municipal Hospital, Chifeng Clinical Medical School of Inner Mongolia Medical University, Chifeng, China.
Biomed Res Int. 2021 Jul 14;2021:9995384. doi: 10.1155/2021/9995384. eCollection 2021.
Human Runt-associated transcription factor 3 (RUNX3) plays an important role in the development and progression of endometrial cancer (EC). However, the clinical and pathological significance of RUNX3 in EC needs to be further studied. In order to clarify the clinical and pathological significance of RUNX3, a systematic review and meta-analysis was conducted in EC patients. Keywords RUNX3, endometrial cancer, and uterine cancer were searched in Cochrane Library, Web of Knowledge, PubMed, CBM, MEDLINE, and Chinese CNKI database for data up to Dec 31, 2018. References, abstracts, and meeting proceedings were manually searched in supplementary. Outcomes were various clinical and pathological features. The two reviewers performed the literature searching, data extracting, and method assessing independently. Meta-analysis was performed by RevMan5.3.0. A total of 563 EC patients were enrolled from eight studies. Meta-analysis results showed that the expression of RUNX3 has significant differences in these comparisons: lymph node (LN) metastasis vs. non-LN metastasis ( = 0.26), EC tissues vs. normal tissues ( < 0.00001), clinical stages I/II vs. II/IV ( < 0.00001), muscular infiltration < 1/2 vs. muscular infiltration ≥ 1/2 ( < 0.00001), and G1 vs. G2/G3 ( < 0.00001). The decreasing expression of RUNX3 is associated with poor TNM stage and muscular infiltration. It is indicated that RUNX3 was involved in the suppression effect of EC. However, further multicenter randomized controlled trials are needed considering the small sample size of the included trials.
人类 runt 相关转录因子 3（RUNX3）在子宫内膜癌（EC）的发生和发展中起重要作用。然而，RUNX3 在 EC 中的临床和病理意义仍需进一步研究。为了阐明 RUNX3 的临床和病理意义，对 EC 患者进行了系统评价和荟萃分析。关键词 RUNX3、子宫内膜癌和子宫癌在 Cochrane Library、Web of Knowledge、PubMed、CBM、MEDLINE 和中国 CNKI 数据库中进行了检索，检索数据截至 2018 年 12 月 31 日。参考文献、摘要和会议记录在补充材料中进行了手动搜索。结果是各种临床和病理特征。两名审查员独立进行文献检索、数据提取和方法评估。使用 RevMan5.3.0 进行荟萃分析。共有 8 项研究纳入了 563 名 EC 患者。荟萃分析结果表明，RUNX3 的表达在以下比较中有显著差异：淋巴结（LN）转移与非 LN 转移（ = 0.26）、EC 组织与正常组织（ < 0.00001）、临床分期 I/II 与 II/IV（ < 0.00001）、肌层浸润<1/2 与肌层浸润≥1/2（ < 0.00001）和 G1 与 G2/G3（ < 0.00001）。RUNX3 表达下调与不良 TNM 分期和肌层浸润有关。这表明 RUNX3 参与了 EC 的抑制作用。然而，考虑到纳入试验的样本量较小，需要进一步进行多中心随机对照试验。
