影像学和非影像学 axSpA 患者的骶髂关节的活动性炎症和慢性结构损伤。
Active Inflammatory and Chronic Structural Damages of Sacroiliac Joint in Patients With Radiographic Axial Spondyloarthritis and Non-Radiographic Axial Spondyloarthritis.
机构信息
Department of Rheumatology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Department of Radiology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
出版信息
Front Immunol. 2021 Jul 27;12:700260. doi: 10.3389/fimmu.2021.700260. eCollection 2021.
OBJECTIVE
Evaluate the MRI evidence of active inflammatory and chronic structural damages in radiographic axial spondyloarthritis (r-axSpA) and non-radiographic axial spondyloarthritis (nr-axSpA).
METHODS
A retrospective review of 253 patients who underwent sacroiliac joint (SIJ) MRI between June 2014 and December 2019 was performed. MRI images including short tau inversion recovery scan and T1-weighted spin echo scans were assessed using the Spondyloarthritis Research Consortium of Canada (SPARCC) score and SPARCC MRI SIJ structural score by two independent readers.
RESULTS
Higher mean score of inflammatory (SPARCC) was seen in r-axSpA patients when compared with nr-axSpA patients (8.08 4.37, <0.05). Frequencies of MRI structural lesions in r-axSpA patients and nr-axSpA patients were as follows: erosion (65.84 88.23%, =0.002), backfill (33.17 13.73%, <0.001), fat metaplasia (79.21 60.78%, =0.01), and ankylosis (37.13 1.96%, <0.001). Patients with r-axSpA had a higher mean score for fat metaplasia (8.93 4.06, =0.0003) and ankylosis (4.49 0.04, <0.001).
CONCLUSION
More active inflammatory and chronic structural damages except for erosion were seen in r-axSpA patients than nr-axSpA patients, while higher percentage of nr-axSpA patients presented with erosion in MRI.
目的
评估影像学轴性脊柱关节炎（r-axSpA）和非影像学轴性脊柱关节炎（nr-axSpA）的 MRI 证据中活跃的炎症和慢性结构损伤。
方法
对 2014 年 6 月至 2019 年 12 月期间接受骶髂关节（SIJ）MRI 检查的 253 例患者进行了回顾性分析。两名独立的读者使用脊柱关节炎研究协会加拿大（SPARCC）评分和 SPARCC MRI SIJ 结构评分评估包括短 tau 反转恢复扫描和 T1 加权自旋回波扫描的 MRI 图像。
结果
与 nr-axSpA 患者相比，r-axSpA 患者的炎症（SPARCC）平均评分更高（8.08 ± 4.37，<0.05）。r-axSpA 患者和 nr-axSpA 患者的 MRI 结构病变频率如下：侵蚀（65.84%±88.23%，=0.002）、填充（33.17%±13.73%，<0.001）、脂肪化生（79.21%±60.78%，=0.01）和强直（37.13%±1.96%，<0.001）。r-axSpA 患者的脂肪化生（8.93 ± 4.06，=0.0003）和强直（4.49 ± 0.04，<0.001）评分更高。
结论
与 nr-axSpA 患者相比，r-axSpA 患者的活跃炎症和慢性结构损伤除了侵蚀外更多，而在 MRI 中，nr-axSpA 患者的侵蚀发生率更高。
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