Monash Centre for Health Research and Implementation (MCHRI), Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3168, Australia.
Int J Mol Sci. 2021 Sep 29;22(19):10559. doi: 10.3390/ijms221910559.
The novel coronavirus severe acute respiratory syndrome () has progressed rapidly from an outbreak to a global pandemic, with new variants rapidly emerging. Coronavirus disease 2019 (COVID-19), the disease resulting from infection, can lead to multiorgan damage. Due to the extremely contagious and fatal nature of the virus, it has been a priority of medical research to find effective means of treatment. Amid this search, the role of vitamin D in modulating various aspects of the innate and adaptive immune system has been discussed. This review aims to consolidate the research surrounding the role of vitamin D in the treatment and prevention of COVID-19. While there are some conflicting results reported, the consensus is that vitamin D has a host of immunomodulatory effects which may be beneficial in the context of COVID-19 and that low levels of vitamin D can result in dysfunction of crucial antimicrobial effects, potentially contributing to poor prognosis. Studies also show that the effects of low vitamin D can be mitigated via supplementation, although the benefits of vitamin D supplementation in the treatment of COVID-19 remain controversial.
新型冠状病毒严重急性呼吸综合征（SARS-CoV-2）迅速从局部爆发演变为全球大流行，新的变异株不断出现。由 感染引起的 2019 年冠状病毒病（COVID-19）可导致多器官损伤。由于该病毒具有极强的传染性和致命性，因此寻找有效的治疗方法一直是医学研究的重点。在这一探索过程中，维生素 D 在调节先天和适应性免疫系统的各个方面的作用受到了讨论。本综述旨在整合围绕维生素 D 在 COVID-19 治疗和预防中的作用的研究。尽管有一些相互矛盾的结果报告，但共识是维生素 D 具有多种免疫调节作用，在 COVID-19 背景下可能有益，而维生素 D 水平低会导致关键抗菌作用的功能障碍，可能导致预后不良。研究还表明，通过补充可以减轻低维生素 D 的影响，尽管维生素 D 补充在 COVID-19 治疗中的益处仍存在争议。
