合并人乳头瘤病毒感染的HIV阳性女性血脂异常患病率：一项初步研究。

Prevalence of Dyslipidemia in HIV-Positive Women with HPV Coinfection: A Preliminary Study.

作者信息

Machado de Carvalho Mônika, Donato Fook Karina, José Abigail Mendes Araújo Maria, Janayna Araújo Guimarães Sulayne, Penha Abreu Souza Camila, Déa Trindade Barbosa Carla, Cléa Cutrim Diniz de Morais Ana, Costa de Sales Muniz Alessandra, Rocha de Araújo Deborah, Bezerra Lima Bertolaccini Maria Fernanda, Kassandra Pereira Belfort Ilka, de Souza Andrade Marcelo, Cristina Moutinho Monteiro Sally

机构信息

Postgraduate Student in Adult Health Program of Federal University of Maranhão-(UFMA) and Professional of Clinical Analysis and Histocompatibility of University Hospital of Federal University of Maranhão (UFMA), São Luís, Brazil.

Laboratory Professional of Clinical Analysis and Histocompatibility of Universitary Hospital of Federal University of Maranhão (UFMA), São Luís, Brazil.

出版信息

Scientifica (Cairo). 2021 Nov 2;2021:4318423. doi: 10.1155/2021/4318423. eCollection 2021.

DOI:10.1155/2021/4318423

PMID:34765266

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8577936/

Abstract

OBJECTIVE

The present study aimed to evaluate the lipid profile and atherogenic indexes in HIV-positive women with and without coinfection with human papillomavirus.

METHODS

Preliminary study was conducted with HIV-positive women. Laboratory tests (lipid profile, glycid profile, and atherogenic indexes) and detection of human papillomavirus (nested PCR technique using PGMY 09 and 11 primers, GP+5, and GP+6) were performed. For the analysis of the results, the data were categorized into two groups: with coinfection (HIV+/HPV+) and without coinfection (HIV+/HPV-).

RESULTS

Eighty-two HIV-positive women, aged between 35 and 49 years, participated in this study among whom 50% had HPV coinfection (HIV+/HPV+). Regarding comorbidities, there was a predominance of dyslipidemia (46.3%). The analysis of laboratory determinations and atherogenic indexes showed statistical relevance in the serum concentrations of total cholesterol (=0.04), LDL cholesterol (=0.03), and non-HDL cholesterol (=0.04), as well as for the Castelli I index, Castelli II index, and atherogenic coefficient (=0.04, 0.04, and 0.03, respectively).

CONCLUSION

The present study demonstrated a correlation between the lipid profile and atherogenic indexes with HIV/HPV coinfection, demonstrating a possible synergy between these viruses. However, further studies in this area must be carried out.

摘要

目的

本研究旨在评估合并或未合并人乳头瘤病毒感染的HIV阳性女性的血脂水平和动脉粥样硬化指数。

方法

对HIV阳性女性进行初步研究。进行了实验室检测（血脂水平、糖代谢指标和动脉粥样硬化指数）以及人乳头瘤病毒检测（使用PGMY 09和11引物、GP+5和GP+6的巢式PCR技术）。为分析结果，将数据分为两组：合并感染组（HIV+/HPV+）和未合并感染组（HIV+/HPV-）。

结果

82名年龄在35至49岁之间的HIV阳性女性参与了本研究，其中50%合并HPV感染（HIV+/HPV+）。关于合并症，血脂异常最为常见（46.3%）。实验室检测结果和动脉粥样硬化指数分析显示，总胆固醇（=0.04）、低密度脂蛋白胆固醇（=0.03）和非高密度脂蛋白胆固醇（=0.04）的血清浓度以及卡斯泰利I指数、卡斯泰利II指数和动脉粥样硬化系数（分别为=0.04、0.04和0.03）具有统计学意义。