Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, Guangdong, People's Republic of China.
Guangdong Provincial Key Laboratory of Digestive Cancer Research, The Seventh Affiliated Hospital of Sun Yat-Sen University, No. 628 Zhenyuan Road, Shenzhen, 518107, Guangdong, People's Republic of China.
Stem Cell Res Ther. 2022 Jan 10;13(1):10. doi: 10.1186/s13287-021-02686-y.
Hippo pathway is initially identified as a master regulator for cell proliferation and organ size control, and the subsequent researches show this pathway is also involved in development, tissue regeneration and homeostasis, inflammation, immunity and cancer. YAP/TAZ, the downstream effectors of Hippo pathway, usually act as coactivators and are dependent on other transcription factors to mediate their transcriptional outputs. In this review, we will first provide an overview on the core components and regulations of Hippo pathway in mammals, and then systematically summarize the identified transcriptional factors or partners that are responsible for the transcriptional output of YAP/TAZ in stem cell and differentiation. More than that, we will discuss the potential applications and future directions based on these findings.
Hippo 通路最初被确定为细胞增殖和器官大小控制的主调控因子，随后的研究表明该通路还参与发育、组织再生和稳态、炎症、免疫和癌症。Hippo 通路的下游效应物 YAP/TAZ 通常作为共激活因子，依赖于其他转录因子来介导其转录输出。在这篇综述中，我们首先概述了哺乳动物 Hippo 通路的核心成分和调控机制，然后系统地总结了负责干细胞和分化中 YAP/TAZ 转录输出的已鉴定转录因子或伴侣。不仅如此，我们还将根据这些发现讨论潜在的应用和未来方向。
