Chang Cheng-Chieh, Wu Szu-Ying, Lai Yun-Ru, Hung Yu-Chiang, Hsu Chung Y, Chen Hsuan-Ju, Chu Cheng-Chung, Cheng Jai-Hong, Hu Wen-Long, Kuo Chun-En Aurea
Department of Chinese Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No. 123, Dapi Rd., Niaosong Dist., Kaohsiung 833, Taiwan.
School of Chinese Medicine for Post Baccalaureate I-Shou University, No.1, Sec. 1, Syuecheng Rd., Dashu District, Kaohsiung 84001, Taiwan.
Evid Based Complement Alternat Med. 2022 Mar 19;2022:5500604. doi: 10.1155/2022/5500604. eCollection 2022.
Traditional Chinese Medicine (TCM) relieves associated symptoms of hyperthyroidism such as heat intolerance, palpitations, tremor, anxiety, weight loss, increased frequency of bowel movements, and shortness of breath. However, there are no studies regarding the core prescription patterns of herbal formula and single herbs for hyperthyroidism in Taiwan.
This is a retrospective, observational study using the National Health Insurance Research Database (NHIRD) in Taiwan to analyze the prescription patterns of TCM. Demographic factors, such as sex, age, occupational status, and residential area, and the risk factors for hyperthyroidism were also studied.
The outpatient or/and inpatient services for hyperthyroidism receive 17,707 cases in a year. Overall, there were 13,394 newly diagnosed patients. TCM was used in 73% of the patients, and 77.3% of the patients were females. The acceptability of TCM was higher among female patients. Most patients were diagnosed with hyperthyroidism between the ages of 30 and 49 years. The most common comorbidity identified was diabetes mellitus. The most commonly prescribed Chinese herbal product (CHP) formula was Jia-Wei-Xia-Yao-San, while Xia-Ku-Cao was the most commonly prescribed single CHP. There was a high coprescription rate for Xuan-Shen, Bei-Mu, and Mu-Li.
This study describes the core prescription pattern of TCM used in the treatment of patients with hyperthyroidism in Taiwan. The most frequently used CHPs could be potential candidates for future pharmacologic studies or clinical trials.
中医可缓解甲状腺功能亢进的相关症状，如不耐热、心悸、震颤、焦虑、体重减轻、排便频率增加和呼吸急促。然而，台湾尚无关于治疗甲状腺功能亢进的中药复方及单味中药核心处方模式的研究。
这是一项回顾性观察研究，利用台湾全民健康保险研究数据库（NHIRD）分析中医处方模式。还研究了人口统计学因素，如性别、年龄、职业状况和居住地区，以及甲状腺功能亢进的危险因素。
甲状腺功能亢进的门诊和/或住院服务每年有17707例病例。总体而言，有13394例新诊断患者。73%的患者使用了中医，77.3%的患者为女性。女性患者对中医的接受度更高。大多数患者在30至49岁之间被诊断为甲状腺功能亢进。最常见的合并症是糖尿病。最常用的中药配方是加味夏枯草散，而夏枯草是最常用的单味中药。玄参、贝母和牡蛎的联合用药率很高。
本研究描述了台湾用于治疗甲状腺功能亢进患者的中医核心处方模式。最常用的中药可能是未来药理研究或临床试验的潜在候选药物。
