Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Rheumatology, Istanbul, Turkey.
Kartal Dr. Lutfi Kirdar Training and Research Hospital, Department of Rheumatology, Istanbul, Turkey.
Reumatol Clin (Engl Ed). 2022 Apr;18(4):227-230. doi: 10.1016/j.reumae.2021.02.009.
Exertional leg pain (ELP) and enthesitis are musculoskeletal findings in familial Mediterranean fever (FMF). They are not accepted as principal treatment targets. In this study, we assessed the effectiveness of treatments on ELP and enthesitis.
We have included 218 FMF patients to the study. We retrospectively compared the FMF attacks' frequency, duration and intensity (FMF attack VAS score) and levels of ELP VAS and enthesitis VAS scores between pre-treatment stage and while patients were on treatment at the last visit.
Forty-nine (22.5%) and 52 (23.9%) of the patients had enthesitis and ELP respectively. All patients were on colchicine treatment. Serositis attacks respond the treatments significantly. Moreover, both ELP VAS scores (p=0.002) and enthesis VAS scores (p=0.17) were improved with treatment. But only improvement in ELP VAS scores was significant.
FMF treatments had favourable effect on ELP and enthesitis in FMF patients. However, the response rates would be inadequate. Therefore, there would be unmet need for treatment of both conditions.
运动相关性腿部疼痛（ELP）和肌腱附着点炎是家族性地中海热（FMF）的肌肉骨骼表现，但它们不被视为主要的治疗靶点。在本研究中，我们评估了治疗对 ELP 和肌腱附着点炎的疗效。
我们共纳入 218 例 FMF 患者。我们回顾性比较了治疗前和最后一次就诊时治疗期间的 FMF 发作频率、持续时间和强度（FMF 发作 VAS 评分）以及 ELP VAS 和肌腱附着点炎 VAS 评分。
49 例（22.5%）和 52 例（23.9%）患者分别存在肌腱附着点炎和 ELP。所有患者均接受秋水仙碱治疗。胸膜炎发作对治疗有显著反应。此外，ELP VAS 评分（p=0.002）和肌腱附着点炎 VAS 评分（p=0.17）均随治疗而改善，但仅 ELP VAS 评分的改善有统计学意义。
FMF 治疗对 FMF 患者的 ELP 和肌腱附着点炎有良好的疗效。然而，反应率可能不足，因此，这两种疾病的治疗需求可能无法得到满足。
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