Removal of hazardous radioactive materials such as Eu from active waste using the batch approach has attracted attention nowadays. In this work, a novel melamine-terephthalic strontium metal-organic framework (MTSr-MOF) was prepared a hydrothermal method. The MTSr-MOF was characterized by various analytical techniques such as FT-IR, H/C-NMR, mass spectroscopy, XPS, XRD, TGA, BET, FE-SEM/EDX, TEM, and UV. The obtained data revealed that MTSr-MOF exhibited brick-like building blocks that were bridged together by the linkers, and each block had a thickness of ∼120 nm. The BET surface area was 74.04 m g. MTSr-MOF was used for the removal of Eu radionuclides from active waste. Further functionalization using various modifiers, including oxalic acid, EDTA, sulfuric acid, and sodium hydroxide was carried out to improve the sorption efficiency of MTSr-MOF towards Eu radionuclides. Among them, MTSr-MOF modified with oxalic acid (MTSr-OX-MOF) demonstrated a superior removal efficiency toward Eu radionuclides when compared to MTSr-MOF or other published reports, with a removal efficiency of more than 96%. The higher sorption efficiency of the MTSr-OX-MOF indicates that it could be a promising candidate for the removal of Eu radionuclides from radioactive waste.