Center for Nanomedicine and Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Zhuhai Precision Medical Center, Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Hospital Affiliated with Jinan University (Zhuhai People's Hospital), Zhuhai, Guangdong 519000, China.
Chem Soc Rev. 2022 Jun 20;51(12):4996-5041. doi: 10.1039/d1cs01148k.
Traditional treatments such as chemotherapy and surgery usually cause severe side effects and excruciating pain. The emergence of nanomedicines and minimally invasive therapies (MITs) has brought hope to patients with malignant diseases. Especially, minimally invasive nanomedicines (MINs), which combine the advantages of nanomedicines and MITs, can effectively target pathological cells/tissues/organs to improve the bioavailability of drugs, minimize side effects and achieve painless treatment with a small incision or no incision, thereby acquiring good therapeutic effects. In this review, we provide a comprehensive review of the research status and challenges of MINs, which generally refers to the medical applications of nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging. Additionally, we also discuss their combined application in various fields including cancers, cardiovascular diseases, tissue engineering, neuro-functional diseases, and infectious diseases. The prospects, and potential bench-to-bedside translation of MINs are also presented in this review. We expect that this review can inspire the broad interest for a wide range of readers working in the fields of interdisciplinary subjects including (but not limited to) chemistry, nanomedicine, bioengineering, nanotechnology, materials science, pharmacology, and biomedicine.
传统的治疗方法，如化疗和手术，通常会引起严重的副作用和剧痛。纳米医学和微创治疗（MIT）的出现给恶性疾病患者带来了希望。特别是微创纳米药物（MINs），结合了纳米药物和 MIT 的优点，可以有效地靶向病理细胞/组织/器官，提高药物的生物利用度，最大限度地减少副作用，并实现微创治疗，切口小或无切口，从而获得良好的治疗效果。在这篇综述中，我们全面回顾了 MINs 的研究现状和挑战，MINs 通常是指纳米技术在光/声/辐射/磁介导治疗和成像中的医学应用。此外，我们还讨论了它们在癌症、心血管疾病、组织工程、神经功能疾病和传染病等各个领域的联合应用。本文还展望了 MINs 的前景和潜在的从实验室到临床的转化。我们希望这篇综述能够激发广泛的兴趣，吸引从事化学、纳米医学、生物工程、纳米技术、材料科学、药理学和生物医学等跨学科领域的读者。
