An extended-reality (XR) platform for real-time monitoring of patients' health during surgical procedures is proposed. The proposed system provides real-time access to a comprehensive set of patients' information, which are made promptly available to the surgical team in the operating room (OR). In particular, the XR platform supports the medical staff by automatically acquiring the patient's vitals from the operating room instrumentation and displaying them in real-time directly on an XR headset. Furthermore, information regarding the patient clinical record is also shown upon request. Finally, the XR-based monitoring platform also allows displaying in XR the video stream coming directly from the endoscope. The innovative aspect of the proposed XR-based monitoring platform lies in the comprehensiveness of the available information, in its modularity and flexibility (in terms of adaption to different sources of data), ease of use, and most importantly, in a reliable communication, which are critical requirements for the healthcare field. To validate the proposed system, experimental tests were conducted using instrumentation typically available in the operating room (i.e., a respiratory ventilator, a patient monitor for intensive care, and an endoscope). The overall results showed (i) an accuracy of the data communication greater than 99 %, along with (ii) an average time response below ms, and (iii) satisfying feedback from the SUS questionnaires filled out by the physicians after intensive use.