Zhang Xinwen, Xiong Hao, Duan Jialin, Chen Xiaomin, Liu Yang, Huang Chunlan
Stem Cell Laboratory and Department of Hematology, Affiliated Hospital of Southwest Medical University, Sichuan Province, Luzhou City, China.
Indian J Hematol Blood Transfus. 2022 Jul;38(3):481-491. doi: 10.1007/s12288-021-01479-w. Epub 2021 Aug 5.
To investigate the expression and clinical significance of Bridging INtegrator 1 () and cyclin D2 () in newly diagnosed cytogenetically heterogenous adult acute myeloid leukemia patients. Real-time quantitative PCR (RQ-PCR) was used to detect the expression of and genes in 49 newly diagnosed adult patients with AML, and their clinical significance was analyzed. and genes are highly expressed in patients with AML, which suggest their potential as molecular markers. A statistical significant correlation was found between expression with bone marrow blasts ( = 0.012), CD34 expression ( = 0.026), NLR ( = 0.019) and Karyotype risk ( = 0.005). There was a statistically significant correlation between and age ( = 0.001), NLR ( = 0.046) Karyotype risk ( = 0.033). The expression level of was related to early treatment response (CR or not) ( = 0.043). expression was significantly correlated with overall survival ( = 0.013), but not with CR ( = 0.731). and genes are highly expressed in patients with AML, suggesting the potential of these two genes as molecular markers. Moreover, high levels of are associated with better prognosis, suggesting the possibility of these two genes as prognostic markers.
探讨衔接整合子1（BIN1）和细胞周期蛋白D2（CCND2）在新诊断的细胞遗传学异质性成人急性髓系白血病患者中的表达及临床意义。采用实时定量聚合酶链反应（RQ-PCR）检测49例新诊断的成人急性髓系白血病患者中BIN1和CCND2基因的表达，并分析其临床意义。BIN1和CCND2基因在急性髓系白血病患者中高表达，提示它们作为分子标志物的潜力。发现BIN1表达与骨髓原始细胞（P = 0.012）、CD34表达（P = 0.026）、中性粒细胞与淋巴细胞比值（NLR）（P = 0.019）和核型风险（P = 0.005）之间存在统计学显著相关性。CCND2与年龄（P = 0.001）、NLR（P = 0.046）、核型风险（P = 0.033）之间存在统计学显著相关性。BIN1的表达水平与早期治疗反应（是否完全缓解）相关（P = 0.043）。CCND2表达与总生存期显著相关（P = 0.013），但与完全缓解无关（P = 0.731）。BIN1和CCND2基因在急性髓系白血病患者中高表达，提示这两个基因作为分子标志物的潜力。此外，高水平的CCND2与较好的预后相关，提示这两个基因作为预后标志物的可能性。
