196543National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
117838Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.
Int J STD AIDS. 2022 Aug;33(9):837-846. doi: 10.1177/09564624221108038. Epub 2022 Jul 2.
This study aims to assess HIV self-testing (HIVST), pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP) uptake and associations of three HIV prevention strategies among men who have sex with men (MSM) in China.
This study included two stages, baseline and follow-up, and was conducted in Harbin, the capital city of Heilongjiang province in North China. MSM were recruited online and by peer-referral. Data contained an online questionnaire and sampling blood for HIV tests. The research group generated a QR code linking to the survey, and participants were asked to scan this QR code with a cellphone to fill out the questionnaire. MSM at the baseline were imparted knowledge of PrEP, PEP and condom use.
Between January 2018 and March 2019, the research team enrolled 773 MSM for baseline analysis, and 699 were HIV negative at baseline. For follow-up, 62% (430/699) participants were retained. At baseline, 11.6% (50/430) of the participants was aware of PrEP and 40.9% (176/430) of PEP; 0.7% (3/430) had ever taken PrEP and 3.3% (14/430) had taken PEP. At follow-up, 77.7% (334/430) reported awareness of PrEP and 54.0% (232/430) for PEP; Only 2.6% (11/430) initiated PrEP uptake and 3.0% (13/430) for PEP. Additionally, at follow-up, only 21 participants newly conducted HIVST. Results showed that being willing to pay for PrEP and PEP uptake was associated with conducting HIVST, and initiations of two HIV prevention methods, PrEP and PEP uptake, were significantly associated with each other.
Knowledge dissemination increased participant awareness and acceptance of PrEP and PEP effectively. Uptake of HIVST, PrEP, and PEP were low and associated with each other. It is promising to achieve high uptake by promoting HIVST, PrEP and PEP as one prevention package.
本研究旨在评估中国男男性行为者（MSM）中 HIV 自我检测（HIVST）、暴露前预防（PrEP）和暴露后预防（PEP）的采用情况，并探讨这三种 HIV 预防策略之间的关联。
本研究分为基线和随访两个阶段，在华北黑龙江省省会哈尔滨进行。MSM 通过线上和同伴推荐招募。数据包括在线问卷和抽样血样进行 HIV 检测。研究小组生成了一个链接到调查的 QR 码，参与者被要求用手机扫描这个 QR 码填写问卷。在基线时，向 MSM 传授了 PrEP、PEP 和 condom 使用知识。
2018 年 1 月至 2019 年 3 月，研究小组招募了 773 名 MSM 进行基线分析，其中 699 名在基线时 HIV 检测结果为阴性。在随访中，62%（430/699）的参与者被保留。在基线时，11.6%（50/430）的参与者了解 PrEP，40.9%（176/430）的参与者了解 PEP；0.7%（3/430）曾服用过 PrEP，3.3%（14/430）曾服用过 PEP。在随访中，77.7%（334/430）报告了解 PrEP，54.0%（232/430）了解 PEP；只有 2.6%（11/430）开始服用 PrEP，3.0%（13/430）开始服用 PEP。此外，在随访中，只有 21 名参与者新进行了 HIVST。结果表明，愿意支付 PrEP 和 PEP 的费用与进行 HIVST 有关，两种 HIV 预防方法的起始，即 PrEP 和 PEP 的使用，与彼此显著相关。
知识传播有效地提高了参与者对 PrEP 和 PEP 的认识和接受度。HIVST、PrEP 和 PEP 的采用率都很低，且相互关联。通过推广 HIVST、PrEP 和 PEP 作为一个预防套餐，有望实现高采用率。
