Department of Pathology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 30 Ostrogórska Str., 41-200 Sosnowiec, Poland.
Silesia LabMed: Centre for Research and Implementation, Medical University of Silesia in Katowice, 18 Medyków Str., 40-752 Katowice, Poland.
Nutrients. 2022 Jun 23;14(13):2604. doi: 10.3390/nu14132604.
Diet plays a crucial role in homeostasis maintenance. Plants and spices containing flavonoids have been widely used in traditional medicine for thousands of years. Flavonols present in our diet may prevent cancer initiation, promotion and progression by modulating important enzymes and receptors in signal transduction pathways related to proliferation, differentiation, apoptosis, inflammation, angiogenesis, metastasis and reversal of multidrug resistance. The anticancer activity of fisetin has been widely documented in numerous in vitro and in vivo studies. This review summarizes the worldwide, evidence-based research on the activity of fisetin toward various types of cancerous conditions, while describing the chemopreventive and therapeutic effects, molecular targets and mechanisms that contribute to the observed anticancer activity of fisetin. In addition, this review synthesized the results from preclinical studies on the use of fisetin as an anticancer agent. Based on the available literature, it might be suggested that fisetin has a bioactive potential to become a complementary drug in the prevention and treatment of cancerous conditions. However, more in-depth research is required to validate current data, so that this compound or its derivatives can enter the clinical trial phase.
饮食在维持体内平衡方面起着至关重要的作用。含有类黄酮的植物和香料在传统医学中被广泛应用已有数千年的历史。饮食中存在的类黄酮可能通过调节与增殖、分化、凋亡、炎症、血管生成、转移和多药耐药逆转相关的信号转导途径中的重要酶和受体，来预防癌症的发生、促进和进展。漆黄素在许多体外和体内研究中已被广泛证明具有抗癌活性。本综述总结了全球范围内基于证据的关于漆黄素对各种癌症状况的活性研究，同时描述了有助于观察到漆黄素抗癌活性的化学预防和治疗作用、分子靶标和机制。此外，本综述还综合了使用漆黄素作为抗癌剂的临床前研究结果。基于现有文献，可能表明漆黄素具有生物活性潜力，可成为预防和治疗癌症的辅助药物。然而，需要进行更深入的研究来验证现有数据，以便使该化合物或其衍生物能够进入临床试验阶段。
