The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan, China.
School of Nursing and Health, Zhengzhou University, Zhengzhou, 450001, Henan, China.
Sci Rep. 2022 Jul 29;12(1):605. doi: 10.1038/s41598-021-02511-9.
This study aimed to examine the validity and reliability of the EORTC QLQ-BR45 questionnaire among breast cancer patients in Ethiopia. This study included 248 breast cancer patients who completed the QLQ-BR45 and QLQ-C30 questionnaires. The internal reliability, test-retest reliability, and the content, concurrent, convergent, divergent, and clinical validity of the tool were examined. The statistical analyses included Cronbach's α coefficient, Pearson's correlation coefficient, standardised root mean square residual (SRMR), comparative fit index (CFI), t-test, and root mean square error of approximation (RMSEA). All items were marked as relevant, and item-level content validity index (I-CVI) scores ranged from 0.83 to 1. The S-CVI/Ave was calculated by dividing the sum of I-CVI values by the total number of items, which was found to be 0.94. The average CVR value was 0.76. The Cronbach's α coefficient was 0.80 for all domains. All subscales met the minimal standards of reliability except the arm symptom scale (0.66). The test-retest reliability coefficient was 0.77 for all domains. Seven out of the 12 hypothesised scales showed positive correlations (r > 0.40) between the QLQ-BR45 and QLQ-C30 scales. Multitrait scaling analysis showed that the item-scale correlations exceeded the 0.40 criterion for item-convergent validity for 11 of the 12 hypothesised scales. The correlation coefficients between an item and its own subscale were significantly higher than with other subscales. The EORTC QLQ-BR45 had good reliability and validity, and it can be used to measure the quality of life of breast cancer patients in Ethiopia.
本研究旨在检验 EORTC QLQ-BR45 问卷在埃塞俄比亚乳腺癌患者中的有效性和可靠性。本研究纳入了 248 例乳腺癌患者，他们完成了 QLQ-BR45 和 QLQ-C30 问卷。研究考察了工具的内部信度、重测信度以及内容、同时、收敛、发散和临床有效性。统计分析包括 Cronbach's α 系数、Pearson 相关系数、标准化根均方残差（SRMR）、比较拟合指数（CFI）、t 检验和近似均方根误差（RMSEA）。所有项目均被标记为相关，项目水平内容有效性指数（I-CVI）得分范围为 0.83 至 1。S-CVI/Ave 通过将 I-CVI 值总和除以总项目数计算得出，结果为 0.94。平均 CVR 值为 0.76。所有领域的 Cronbach's α 系数均为 0.80。除手臂症状量表（0.66）外，所有子量表均符合最低可靠性标准。所有领域的重测信度系数均为 0.77。12 个假设量表中有 7 个在 QLQ-BR45 和 QLQ-C30 量表之间显示出正相关（r>0.40）。多特质标度分析显示，12 个假设量表中有 11 个的项目-量表相关性超过了 0.40 的项目收敛有效性标准。项目与其自身子量表之间的相关系数明显高于与其他子量表之间的相关系数。EORTC QLQ-BR45 具有良好的信度和有效性，可用于衡量埃塞俄比亚乳腺癌患者的生活质量。
