Niu Xiaorong, Han Peng, Duan Maoli, Chen Zichen, Hu Juan, Chen Yanfei, Xu Min, Ren Pengyu, Zhang Qing
Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Department of Otolaryngology Head and Neck Surgery, Department of Clinical Science, Intervention and Technology, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
Front Neurol. 2022 Aug 26;13:921133. doi: 10.3389/fneur.2022.921133. eCollection 2022.
To observe the functional status of the otolith pathway in patients with unilateral idiopathic benign paroxysmal positional vertigo (BPPV) by combining air-conducted sound elicited cervical vestibular-evoked myogenic potential (ACS-cVEMP) and ocular vestibular-evoked myogenic potential (ACS-oVEMP).
One hundred and eighty patients with BPPV were recruited for conventional cVEMP and oVEMP tests. The abnormal rates of VEMPs were compared between BPPV patients and control participants.
The abnormal rates of cVEMP and oVEMP in BPPV patients were 46.7% (84/180) and 57.2% (103/180) in affected ears, respectively, and 45.0% (81/180) and 56.7% (102/180) in unaffected ears, respectively; both were significantly higher than the abnormal rates of cVEMP and oVEMP in normal control ears. Compared with normal subjects, the cVEMP response rate was lower in affected and unaffected ears in BPPV patients. The abnormal rates of cVEMP and oVEMP were 48.1% (76/158) and 57.6% (91/158) in patients with posterior semicircular canal BPPV, and 36.4% (8/22) and 54.5% (12/22) in lateral semicircular canal BPPV. There was no significant difference in VEMP abnormalities between posterior semicircular canal BPPV and lateral semicircular canal BPPV.
The prevalence of abnormal cVEMPs and oVEMPs in both affected and unaffected ears of patients with BPPV was significantly higher than that observed in the control group. The pathological mechanism of unilateral idiopathic BPPV may be associated with bilateral degeneration of otolith pathways.
通过结合气导声音诱发的颈前庭诱发肌源性电位（ACS-cVEMP）和眼前庭诱发肌源性电位（ACS-oVEMP），观察单侧特发性良性阵发性位置性眩晕（BPPV）患者耳石通路的功能状态。
招募180例BPPV患者进行常规cVEMP和oVEMP测试。比较BPPV患者与对照参与者之间VEMPs的异常率。
BPPV患者患侧耳cVEMP和oVEMP的异常率分别为46.7%（84/180）和57.2%（103/180），健侧耳分别为45.0%（81/180）和56.7%（102/180）；两者均显著高于正常对照耳cVEMP和oVEMP的异常率。与正常受试者相比，BPPV患者患侧和健侧耳的cVEMP反应率较低。后半规管BPPV患者cVEMP和oVEMP的异常率分别为48.1%（76/158）和57.6%（91/158），水平半规管BPPV患者分别为36.4%（8/22）和54.5%（12/22）。后半规管BPPV和水平半规管BPPV之间VEMP异常无显著差异。
BPPV患者患侧和健侧耳cVEMP和oVEMP异常的发生率显著高于对照组。单侧特发性BPPV的病理机制可能与耳石通路的双侧退变有关。
