Saini Sumit, Nayak Brusabhanu, Singh Prashant, Singh Prabhjot, Nayyar Rishi, Kumar Rajeev, Seth Amlesh
Department of Urology, All India Institute of Medical Sciences (AIIMS), 5033, Teaching Block, Ansari Nagar, New Delhi, 110029 India.
Indian J Surg Oncol. 2022 Sep;13(3):641-646. doi: 10.1007/s13193-022-01544-4. Epub 2022 May 2.
To compare the outcomes between cutaneous ureterostomy and ileal conduit urinary diversion in patients with solitary functioning kidney, undergoing radical cystectomy. This study was a retrospective analysis of the patients, with solitary functioning kidney, who underwent radical cystectomy with either cutaneous ureterostomy or ileal conduit from January 2014 to May 2019. Baseline characteristics, perioperative outcomes, and follow-up renal function were evaluated and compared. For renal function outcomes, we assessed the estimated glomerular filtration rate (eGFR) and included patients with a follow-up of at least 2 years. A total of 43 patients were included in the study, 23 of them underwent cutaneous ureterostomy and 20 underwent ileal conduit urinary diversion. The two groups were similar with respect to their baseline demographic and clinical characteristics. Operative time ( < 0.001), time to drain removal ( = 0.016), postoperative length of hospital stay ( = 0.018), and bowel-related complications ( = 0.047) were significantly lower in patients who underwent cutaneous ureterostomy. The eGFR was comparable at baseline, and till 1 year of follow-up. But, there was a greater decline in eGFR over 2 years, in patients who received cutaneous ureterostomy ( = 0.039). The present study shows that cutaneous ureterostomy has better perioperative, and comparable short-term renal function outcomes over ileal conduit urinary diversion. However, over 2 years of follow-up, there was an increased likelihood, and greater degree of decline in eGFR in patients who received cutaneous ureterostomy.
比较接受根治性膀胱切除术的单功能肾患者行皮肤输尿管造口术和回肠代膀胱术的疗效。本研究对2014年1月至2019年5月期间接受根治性膀胱切除术并行皮肤输尿管造口术或回肠代膀胱术的单功能肾患者进行回顾性分析。评估并比较基线特征、围手术期结局和随访肾功能。对于肾功能结局,我们评估了估计肾小球滤过率(eGFR),纳入随访至少2年的患者。本研究共纳入43例患者,其中23例行皮肤输尿管造口术,20例行回肠代膀胱术。两组在基线人口统计学和临床特征方面相似。行皮肤输尿管造口术的患者手术时间(<0.001)、引流管拔除时间(=0.016)、术后住院时间(=0.018)和肠道相关并发症(=0.047)显著更低。基线时及随访1年时eGFR相当。但是,接受皮肤输尿管造口术的患者2年以上eGFR下降更大(=0.039)。本研究表明,与回肠代膀胱术相比,皮肤输尿管造口术围手术期效果更好,短期肾功能相当。然而,随访2年以上,接受皮肤输尿管造口术的患者eGFR下降的可能性增加,下降程度更大。