绿色合成氧化锌和银纳米粒子的波峰到波谷细胞漂移

Crest to Trough Cellular Drifting of Green-Synthesized Zinc Oxide and Silver Nanoparticles.

作者信息

Hasan Murtaza, Zafar Ayesha, Imran Muhammad, Iqbal Khalid Javed, Tariq Tuba, Iqbal Javed, Shaheen Aqeela, Hussain Riaz, Anjum Syed Ishtiaq, Shu Xugang

机构信息

School of Chemistry and Chemical Engineering, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong Province 510225, P. R. China.

Department of Biotechnology, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

出版信息

ACS Omega. 2022 Sep 20;7(39):34770-34778. doi: 10.1021/acsomega.2c02178. eCollection 2022 Oct 4.

DOI:10.1021/acsomega.2c02178

PMID:36211074

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9535654/

Abstract

Green nanotechnology facilitates the blooming of zinc oxide (ZnO) and silver (Ag) nanoparticles (NPs) with distinct flowerlike and spherical morphologies, respectively. The well-characterized NPs with an average size of 35 nm (ZnO) and 25 nm (Ag) were functionalized on the cresty plates for antibacterial inhibition against and , with the flowerlike ZnONPs exhibiting 90.9% inhibition and AgNPs exhibiting 100% inhibition. Further, the in vivo underwater troughs for hematological, immunological, and serological analysis in exhibited 102 > 575 > 104 and 206 > 109 > 81% at concentrations of 1, 2, and 3 mg/L with 4-day and 15-day treatment, respectively, over ZnONPs. However, AgNPs exhibited 257 > 408 > 124 and 86 > 202 > 43% with 4-day and 15-day treatment, respectively, at the same concentrations. The classical ZnNPs and AgNPs exhibited excellent inhibition potential and significant transfiguration of hematological, enzymological, and protein parameters as safe nanomedicine, but ZnONPs were found to be 58, 69, 29 and 34, 51, 70% more active than AgNPs with 4-day and 15-day treatment, respectively. Therefore, the onset of ROX and antioxidant arena favors beneficial cellular drifting of NPs.

摘要

绿色纳米技术分别促进了具有独特花状和球形形态的氧化锌（ZnO）和银（Ag）纳米颗粒（NPs）的形成。平均粒径为35 nm（ZnO）和25 nm（Ag）的特征明确的纳米颗粒在嵴状板上功能化，用于对[具体细菌1]和[具体细菌2]的抗菌抑制，花状ZnO纳米颗粒表现出90.9%的抑制率，Ag纳米颗粒表现出100%的抑制率。此外，在[具体动物]中用于血液学、免疫学和血清学分析的体内水槽实验表明，在1、2和3 mg/L的浓度下，分别进行4天和15天的处理后，相对于ZnO纳米颗粒，[具体指标1]表现为102 > 575 > 104，[具体指标2]表现为206 > 109 > 81%。然而，在相同浓度下，Ag纳米颗粒在4天和15天处理时分别表现为257 > 408 > 124和86 > 202 > 43%。经典的Zn纳米颗粒和Ag纳米颗粒作为安全的纳米药物表现出优异的抑制潜力以及血液学、酶学和蛋白质参数的显著变化，但发现ZnO纳米颗粒在4天和15天处理时分别比Ag纳米颗粒活性高58%、69%、29%和34%、51%、70%。因此，ROX和抗氧化领域的出现有利于纳米颗粒有益的细胞漂移。