感染对特发性矮小儿童胃饥饿素和胰岛素样生长因子1分泌的影响。

Effects of Infection on Ghrelin and Insulin-like Growth Factor 1 Secretion in Children with Idiopathic Short Stature.

作者信息

Kolasa-Kicińska Marzena, Stawerska Renata, Stawerski Paweł, Kałużyński Andrzej, Czkwianianc Elżbieta, Lewiński Andrzej

机构信息

Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital-Research Institute, 93-338 Lodz, Poland.

Department of Paediatric Endocrinology, Medical University of Lodz, 93-338 Lodz, Poland.

出版信息

J Clin Med. 2022 Oct 4;11(19):5868. doi: 10.3390/jcm11195868.

DOI:10.3390/jcm11195868

PMID:36233735

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9572010/

Abstract

BACKGROUND

A diagnosis of "idiopathic short stature" (ISS) in a child means that the cause of the disease has not been established, although there are certainly some unknown factors that contributed to its occurrence. Ghrelin and leptin are important in controlling food intake; ghrelin is also a growth hormone (GH) stimulator. Both enterohormones are produced in the stomach and their secretion may be affected by a () infection.

METHODS

Our study included a group of 61 children (53 prepubertal and 8 peripubertal) with ISS, without any gastrointestinal tract symptoms but in whom the histopathological evaluation of stomach tissue was made during gastroscopy to diagnose infection. In each child, fasting ghrelin, leptin and IGF-1 concentrations, and GH levels in two stimulation tests were assessed.

RESULTS

infection was confirmed in 24.6% of the children. Ghrelin and IGF-1 concentrations were significantly lower in -positive than -negative children (this was more noticeable in prepubertal subgroups), however there was not a discrepancy in regards to GH concentrations in stimulation tests, leptin levels or the nutritional state between groups.

CONCLUSIONS

Short children, infected by seem to have lower ghrelin and IGF-1 concentrations than children without infection, this may be the reason for a worse growth rate in this subgroup.

摘要