Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, PR China.
Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, PR China.
Sci Total Environ. 2023 Jan 20;857(Pt 3):159570. doi: 10.1016/j.scitotenv.2022.159570. Epub 2022 Oct 23.
Phthalate metabolites are widely present in humans and can have many adverse effects on pregnant women. To date, many studies on the effects of phthalate metabolites on the risk of gestational diabetes mellitus (GDM) have been published, but the findings of these studies are controversial. We conducted a case-control study to quantify the concentrations of seven phthalate metabolites in the serum of pregnant women and to investigate their association with the risk of GDM and blood glucose levels in pregnant women. Therefore, 201 serum samples (139 pregnant women with GDM and 62 control serum samples) were collected from Hangzhou, China, between 2011 and 2012. The results showed that mono butyl phthalate (MBP; mean = 4.08 ng/mL) was the most abundant phthalate metabolites in human serum, followed by mono (2-ethylhexyl) phthalate (MEHP; mean = 1.28 ng/mL) and mono isobutyl phthalate (MiBP; mean = 1.20 ng/mL). The other results indicated significant associations between MBP (β = 2.24, 95 % confidence interval (CI): 1.02, 5.07, P = 0.050) and MiBP (β = 1.84, 95 % CI: 1.03, 3.31, P = 0.041) concentrations in human serum and the incidence of GDM. Moreover, serum MBP (β = 0.40, 95 % CI: 0.10, 0.70, P = 0.010) and MiBP levels (β = 0.18, 95 % CI: 0.010, 0.35, P = 0.047) in humans were positively associated with 2-hour blood glucose levels. Our study provides affirmative evidence on previously inconsistent findings that MBP and MiBP exposure may increase the risk of GDM in pregnant women.
邻苯二甲酸酯代谢物广泛存在于人体中，对孕妇有许多不良影响。迄今为止，已有许多关于邻苯二甲酸酯代谢物对妊娠糖尿病（GDM）风险影响的研究发表，但这些研究的结果存在争议。我们进行了一项病例对照研究，以量化孕妇血清中七种邻苯二甲酸酯代谢物的浓度，并研究它们与 GDM 风险和孕妇血糖水平的关系。因此，我们于 2011 年至 2012 年期间从中国杭州采集了 201 份血清样本（139 份 GDM 孕妇血清样本和 62 份对照血清样本）。结果表明，邻苯二甲酸单丁酯（MBP；平均值=4.08ng/mL）是人类血清中最丰富的邻苯二甲酸酯代谢物，其次是邻苯二甲酸单（2-乙基己基）酯（MEHP；平均值=1.28ng/mL）和邻苯二甲酸单异丁酯（MiBP；平均值=1.20ng/mL）。其他结果表明，血清 MBP（β=2.24，95%置信区间（CI）：1.02，5.07，P=0.050）和 MiBP（β=1.84，95%CI：1.03，3.31，P=0.041）浓度与 GDM 的发生显著相关。此外，血清 MBP（β=0.40，95%CI：0.10，0.70，P=0.010）和 MiBP 水平（β=0.18，95%CI：0.010，0.35，P=0.047）与 2 小时血糖水平呈正相关。我们的研究提供了肯定的证据，证明之前关于 MBP 和 MiBP 暴露可能增加孕妇患 GDM 风险的不一致发现是正确的。
