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中枢注射脱落酸可减轻慢性应激诱导的雄性小鼠的情绪障碍。

Central injection of abscisic acid attenuates mood disorders induced by subchronic stress in male mice.

机构信息

Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Brain Behav. 2022 Dec;12(12):e2796. doi: 10.1002/brb3.2796. Epub 2022 Nov 10.

DOI:10.1002/brb3.2796
PMID:36355391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9759152/
Abstract

Stressful life increases the risk of mental and psychological disorders and cognitive deficits. Abscisic acid (ABA) is a plant hormone that has been recently discovered in mammalians. ABA is produced in response to stressful stimuli and it can reduce anxiety-like behaviors and depression and improve cognitive function. This study was designed to evaluate the effects of microinjection of ABA on depression, anxiety, passive avoidance learning and memory deficits induced by subchronic stress. ABA (10 and 15  g/mouse, i.c.v.) was administered one week after recovery period for 4 consecutive days. A three-session forced swimming test (FST) protocol for induction of subchronic stress was administered to the mice. Exploratory, anxiety-like behavior, depression and cognitive function were assessed 24 h after the last swim stress session. The results indicated that ABA (15  g/mouse) could ameliorate anxiety and depression induced by FST. In addition, ABA had no effect on the subchronic stress-induced cognitive impairments. Taken together, the results suggest that ABA could improve anxiety and depression induced by subchronic stress.

摘要

压力生活增加了心理和心理障碍和认知缺陷的风险。脱落酸（ABA）是最近在哺乳动物中发现的植物激素。ABA 是对应激刺激产生的，可以减轻类似焦虑的行为和抑郁，并改善认知功能。本研究旨在评估 ABA 微注射对亚慢性应激引起的抑郁、焦虑、被动回避学习和记忆缺陷的影响。ABA（10 和 15 g/mouse，icv）在恢复期后一周给予，连续 4 天给予。对小鼠进行了三阶段强迫游泳试验（FST）方案以诱导亚慢性应激。在最后一次游泳应激后 24 小时评估探索性、焦虑样行为、抑郁和认知功能。结果表明，ABA（15 g/mouse）可改善 FST 诱导的焦虑和抑郁。此外，ABA 对亚慢性应激引起的认知障碍没有影响。总之，结果表明 ABA 可以改善亚慢性应激引起的焦虑和抑郁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/19cff876c4d8/BRB3-12-e2796-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/6750cdb2eede/BRB3-12-e2796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/31c61d7ff645/BRB3-12-e2796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/37e7f7f6319b/BRB3-12-e2796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/0655ff155001/BRB3-12-e2796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/19cff876c4d8/BRB3-12-e2796-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/6750cdb2eede/BRB3-12-e2796-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/31c61d7ff645/BRB3-12-e2796-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/37e7f7f6319b/BRB3-12-e2796-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/0655ff155001/BRB3-12-e2796-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f24/9759152/19cff876c4d8/BRB3-12-e2796-g005.jpg

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