新型冠状病毒肺炎患者嗅觉和味觉的客观评估

Objective Evaluation of Smell and Taste Senses in COVID-19 Patients.

作者信息

Kaya Altan, Altıparmak Serkan, Yaşar Mehmet, Özcan İbrahim, Çelik İlhami

机构信息

Clinic of Otolaryngology, Kayseri City Hospital, Kayseri, Turkey.

Clinic of Infectious Diseases and Clinical Microbiology, Kayseri City Hospital, Kayseri, Turkey.

出版信息

Turk Arch Otorhinolaryngol. 2022 Sep;60(3):128-133. doi: 10.4274/tao.2022.2022-6-1. Epub 2022 Nov 15.

Abstract

OBJECTIVE

The severe acute respiratory syndrome-coronavirus-2 pandemic is one of the largest of the recent times and can cause many symptoms including smell and taste disorders. In the literature, smell disorders caused by coronavirus disease-2019 (COVID-19) have been reported within a wide range from 3.2% to 98.3%. A small number of these studies demonstrated smell and taste disorders through objective tests. Our aim in this study was to determine the prevalence of smell and taste disorders in hospitalized patients due to COVID-19 infection.

METHODS

The study was carried out with 100 patients who were positive for real-time polymerase chain reaction and treated at the Kayseri City Hospital, and 100 healthcare worker relatives. We used the Connecticut Chemosensory Clinical Research Center test to evaluate the sense of smell. Sense of taste was evaluated using four different standardized bottles of preparations, and the results were scored according to the patients' statements.

RESULTS

Patient (Group 1) and control (Group 2) groups were compared for age, gender, smell and taste disorders. There were 39 women and 61 men in the patient group, and 40 women and 60 men in the control group. Mean age was 50.2±1.37 (range 21-70) years in Group 1 and 47.6±1.25 (range 18-70) years in Group 2, and there was no significant difference between the two groups. While the rate of smell disorder was 80% in Group 1, we found this rate as 35% in Group 2. Taste disturbance was identified in 38 patients, of whom 16 had mild hypogeusia, 17 had moderate hypogeusia, four had severe hypogeusia, and one patient had ageusia. We found that taste disorder was 38% in Group 1 and 3% in Group 2.

CONCLUSION

Smell and taste dysfunctions are very common symptoms in COVID-19 patients. The results obtained using objective test methods are higher than the rates obtained from patient statements.

摘要

目的

严重急性呼吸综合征冠状病毒2大流行是近年来规模最大的疫情之一,可引发包括嗅觉和味觉障碍在内的多种症状。在文献中,2019冠状病毒病(COVID-19)导致的嗅觉障碍报告发生率在3.2%至98.3%的广泛范围内。这些研究中少数通过客观测试证实了嗅觉和味觉障碍。本研究的目的是确定因COVID-19感染住院患者中嗅觉和味觉障碍的患病率。

方法

该研究纳入了100例实时聚合酶链反应检测呈阳性且在开塞利市医院接受治疗的患者,以及100名医护人员亲属。我们使用康涅狄格化学感觉临床研究中心测试来评估嗅觉。使用四瓶不同的标准化制剂评估味觉,并根据患者的陈述对结果进行评分。

结果

比较了患者组(第1组)和对照组(第2组)的年龄、性别、嗅觉和味觉障碍情况。患者组有39名女性和61名男性,对照组有40名女性和60名男性。第1组的平均年龄为50.2±1.37(范围21 - 70)岁,第2组为47.6±1.25(范围18 - 70)岁,两组之间无显著差异。第1组嗅觉障碍发生率为80%,而第2组为35%。38例患者存在味觉障碍,其中16例为轻度味觉减退,17例为中度味觉减退,4例为重度味觉减退,1例患者为味觉丧失。我们发现第1组味觉障碍发生率为38%,第2组为3%。

结论

嗅觉和味觉功能障碍是COVID-19患者非常常见的症状。使用客观测试方法得到的数据高于患者陈述得出的数据。

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