68Ga-FAPI-04 与氟-18-氟代脱氧葡萄糖 PET/CT 在卵巢恶性肿瘤检测中的比较。

Comparison of 68 Ga-FAPI-04 and fluorine-18-fluorodeoxyglucose PET/computed tomography in the detection of ovarian malignancies.

机构信息

Faculty of Chinese Medicine, Macau University of Science and Technology.

State Key Laboratory of Quality Research in Chinese Medicine (Macau University of Science and Technology), Macau.

出版信息

Nucl Med Commun. 2023 Mar 1;44(3):194-203. doi: 10.1097/MNM.0000000000001653. Epub 2022 Dec 7.

DOI:10.1097/MNM.0000000000001653

PMID:36472415

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9907692/

Abstract

BACKGROUND

Currently, fluorine-18-fluorodeoxyglucose ( 18 F-FDG) is the most frequently used diagnostical radiotracer for PET/computed tomography (PET/CT) in ovarian malignancies. However, 18 F-FDG has some limitations. The fibroblast activation protein inhibitor (FAPI) previously demonstrated highly promising results in studies on various tumor entities and 68 Ga-labeled FAPI presents a promising alternative to 18 F-FDG. This study aimed to compare the performance of 68 Ga-FAPI and 18 F-FDG PET/CT for imaging of ovarian malignancies.

METHODS

A total of 27 patients were included in this retrospective study conducted at the Affiliated Hospital of Southwest Medical University between June 2020 and February 2022. The 18 F-FDG and 68 Ga-FAPI uptakes of tumors, lymph nodes, and distant metastases were quantified using the maximum standardized uptake values, and the tumor-to-background ratios were also evaluated and calculated by using the Wilcoxon signed-rank test.

RESULTS

Twenty-one patients with suspected ( n = 11) and previously treated ovarian malignancies ( n = 10) were in statistical analysis finally. For detecting tumors, 68 Ga-FAPI PET/CT was more sensitive than 18 F-FDG PET/CT [14 of 14 (100%) vs. 11 of 14 (78%)], lymph node metastases [75 of 75 (100%) vs. 60 of 75 (80%)] and superior to 18 F-FDG PET/CT in terms of the peritoneal and pleural metastases [9 of 9 (100%) vs. 5 of 9 (56%)]. For four of the newly diagnosed patients ( n = 11), 68 Ga-FAPI PET/CT upstaged the clinical stage compared to 18 F-FDG PET/CT.

CONCLUSION

68 Ga-FAPI PET/CT has superior potential in the detection of ovarian cancers, especially in peritoneal carcinomatosis. 68 Ga-FAPI PET/CT may be a promising supplement for staging and follow-up of ovarian malignancies.

摘要

背景

目前，18 氟-氟代脱氧葡萄糖（18 F-FDG）是卵巢恶性肿瘤正电子发射断层扫描/计算机断层扫描（PET/CT）中最常用的诊断性放射性示踪剂。然而，18 F-FDG 存在一些局限性。成纤维细胞激活蛋白抑制剂（FAPI）在各种肿瘤实体的研究中表现出了非常有前景的结果，68 Ga 标记的 FAPI 是 18 F-FDG 的有前途的替代品。本研究旨在比较 68 Ga-FAPI 和 18 F-FDG PET/CT 对卵巢恶性肿瘤成像的性能。

方法

本回顾性研究于 2020 年 6 月至 2022 年 2 月在西南医科大学附属医院进行，共纳入 27 例患者。使用最大标准化摄取值对肿瘤、淋巴结和远处转移的 18 F-FDG 和 68 Ga-FAPI 摄取进行定量，并使用 Wilcoxon 符号秩检验评估和计算肿瘤与背景的比值。

结果

最终对 21 例疑似（n = 11）和先前治疗的卵巢恶性肿瘤（n = 10）患者进行了统计学分析。在检测肿瘤方面，68 Ga-FAPI PET/CT 比 18 F-FDG PET/CT 更敏感[14 例（100%）比 11 例（78%）]，对淋巴结转移的敏感性更高[75 例（100%）比 60 例（80%）]，对腹膜和胸膜转移的敏感性也更高[9 例（100%）比 5 例（56%）]。在 4 例新诊断的患者（n = 11）中，68 Ga-FAPI PET/CT 比 18 F-FDG PET/CT 更准确地分期。