食管鳞状细胞癌中神经周围侵犯的模式和预后预测价值。

Patterns and prognostic predictive value of perineural invasion in esophageal squamous cell carcinoma.

机构信息

Department of Pathology, Shaanxi Provincial People's Hospital, Xi'an, 710068, People's Republic of China.

Department of Anesthesiology, Shaanxi Provincial People's Hospital, Xi'an, 710068, People's Republic of China.

出版信息

BMC Cancer. 2022 Dec 8;22(1):1287. doi: 10.1186/s12885-022-10386-w.

DOI:10.1186/s12885-022-10386-w

PMID:36482313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9733208/

Abstract

BACKGROUND

The pathological phenotype of perineural invasion (PNI) in squamous cell carcinoma (ESCC) is prevalent but highly heterogeneous.

METHODS

Postoperative specimens from all patients with ESCC at Shaanxi Provincial People's Hospital were evaluated for PNI using haematoxylin and eosin (H&E) staining and S100 immunohistochemistry (IHC). We determined the correlation between PNI status and clinical outcomes.

RESULTS

Among 349 ESCC cases, PNI was identified in 127 patients (36.3%), and four subtypes of PNI were identified in our study. Correlation analysis confirmed that PNI was related to tumour invasion depth (pT stage) and lymph node status (pN stage) (P < 0.05). Multivariate analysis showed that PNI (P = 0.001) was an independent factor affecting disease-free survival (DFS) in ESCC, and a similar result was found for overall survival (OS) (P = 0.017). Further analysis revealed that PNI status was a prognostic factor of DFS (P < 0.001) and OS (P = 0.003) exclusively in pN-negative patients. We also found that patients with the PNI-a subtype had better DFS (P = 0.002) and OS (P = 0.002) than patients with the other three subtypes (PNI-b, c, d).

CONCLUSION

The pathological phenotypes of PNI are diverse, and the identification of PNI subtypes has important clinical guiding value.

摘要

背景

鳞状细胞癌（ESCC）中神经周围侵犯（PNI）的病理表型普遍存在，但高度异质。

方法

陕西人民医院所有 ESCC 术后标本均采用苏木精和伊红（H&E）染色和 S100 免疫组织化学（IHC）评估 PNI。我们确定了 PNI 状态与临床结局之间的相关性。

结果

在 349 例 ESCC 病例中，127 例（36.3%）患者存在 PNI，本研究确定了 4 种 PNI 亚型。相关性分析证实 PNI 与肿瘤浸润深度（pT 分期）和淋巴结状态（pN 分期）相关（P<0.05）。多变量分析显示，PNI（P=0.001）是影响 ESCC 无病生存（DFS）的独立因素，在总生存（OS）中也发现了类似的结果（P=0.017）。进一步分析表明，PNI 状态是 DFS（P<0.001）和 OS（P=0.003）的预后因素，仅在 pN 阴性患者中如此。我们还发现，PNI-a 亚型患者的 DFS（P=0.002）和 OS（P=0.002）优于其他三种亚型（PNI-b、c、d）的患者。