埃塞俄比亚南部哈瓦萨市公立医院孕妇中乙肝病毒的血清流行率及相关因素:横断面研究设计

Sero-prevalence and associated factors of hepatitis B virus among pregnant women in Hawassa city public hospitals, Southern Ethiopia: Cross-sectional study design.

作者信息

Kassaw Birku, Abera Netsanet, Legesse Tegene, Workineh Alemu, Ambaw Gizachew

机构信息

School of Public Health, College of Health Science and Medicine, Hawassa University, Hawassa, Ethiopia.

School of Public Health, College of Health Science and Medicine, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

出版信息

SAGE Open Med. 2022 Dec 6;10:20503121221140778. doi: 10.1177/20503121221140778. eCollection 2022.

Abstract

OBJECTIVE

This study aimed to determine the prevalence and identify associated factors of hepatitis B virus infection among pregnant women attending antenatal care (ANC) follow-up.

METHODS

An institution-based cross-sectional study was conducted from March 04 to April 03, 2020. A total of 381 women were selected using systematic random sampling after every two consecutive women. Structured and interviewer administered questionnaire was used to collect the data. A 2 ml of venous blood sample was drawn from each participant. The plasma was separated from the collected blood samples and was analyzed using a rapid hepatitis B surface antigen (HBsAg) kit to determine hepatitis sero status. Data were entered into the EPI-Data version 3.1, then exported to the statistical package for social sciences version 25 software and analyzed. Multivariable logistic regression was performed to identify independent predictors of HBsAg B seroprevalence at a -value <0.05.

RESULTS

The prevalence of HBsAg sero-positivity among pregnant women was 6.6%, 95% CI (4.2, 8.9). History of hosptal admission (adjusted odds ratio (AOR) = 4.11; 95% CI = 1.33-12.71), surgical history (AOR = 6.8; 95% CI = 1.93-23.93), history dental procedures (AOR = 4.93; 95% CI = 1.31-18.53), and body tatoo practices (AOR = 6.822; 95% CI = 1.89-24.69) were found to be associated with HBsAg sero-positivity.

CONCLUSION

This study found that HBsAg sero positivity among pregnant women in the study area was in intermediate edemicity. Factors such as history of hospital admission, history of surgery, history of dental procedures, and body tattoo practices were found to be associated with HBsAg sero-positivity. The government of Ethiopia should strengthen screening of all pregnant women for HBV as a part of routine ANC in ANC clinics and treating if they are positive to prevent mother to child transmission.

摘要

目的

本研究旨在确定接受产前检查(ANC)随访的孕妇中乙型肝炎病毒感染的患病率,并识别相关因素。

方法

于2020年3月4日至4月3日进行了一项基于机构的横断面研究。采用系统随机抽样法,每隔两名连续的妇女选取一名,共选取381名妇女。使用结构化且由访谈员实施的问卷收集数据。从每位参与者采集2毫升静脉血样。将采集的血样分离出血浆,使用快速乙肝表面抗原(HBsAg)检测试剂盒进行分析,以确定肝炎血清学状态。数据录入EPI-Data 3.1版本,然后导出到社会科学统计软件包25版本软件进行分析。进行多变量逻辑回归分析,以确定乙肝表面抗原血清阳性率的独立预测因素,α值<0.05。

结果

孕妇中乙肝表面抗原血清阳性率为6.6%,95%置信区间(4.2,8.9)。住院史(调整比值比(AOR)=4.11;95%置信区间=1.33 - 12.71)、手术史(AOR = 6.8;95%置信区间=1.93 - 23.93)、牙科治疗史(AOR = 4.93;95%置信区间=1.31 - 18.53)和纹身史(AOR = 6.822;95%置信区间=1.89 - 24.69)被发现与乙肝表面抗原血清阳性有关。

结论

本研究发现,研究地区孕妇中乙肝表面抗原血清阳性处于中等流行程度。住院史、手术史、牙科治疗史和纹身史等因素被发现与乙肝表面抗原血清阳性有关。埃塞俄比亚政府应加强对所有孕妇进行乙肝病毒筛查,作为ANC诊所常规产前检查的一部分,并对阳性者进行治疗,以预防母婴传播。

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