Khbouz Badr, Gu Shiyang, Pinto Coelho Tiago, Lallemand François, Jouret François
Groupe Interdisciplinaire de Génoprotéomique Appliquée (GIGA), Cardiovascular Sciences, University of Liège (ULiège), 4000 Liège, Belgium.
III. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.
Bioengineering (Basel). 2023 Jan 5;10(1):68. doi: 10.3390/bioengineering10010068.
Ionizing irradiation is widely applied as a fundamental therapeutic treatment in several diseases. Acute kidney injury (AKI) represents a global public health problem with major morbidity and mortality. Renal ischemia/reperfusion (I/R) is the main cause of AKI. I/R injury occurs when blood flow to the kidney is transiently interrupted and then restored. Such an ischemic insult significantly impairs renal function in the short and long terms. Renal ischemic preconditioning (IPC) corresponds to the maneuvers intended to prevent or attenuate the ischemic damage. In murine models, irradiation-induced preconditioning (IP) renders the renal parenchyma resistant to subsequent damage by activating defense pathways involved in oxidative stress, angiogenesis, and inflammation. Before envisioning translational applications in patients, safe irradiation modalities, including timing, dosage, and fractionation, need to be defined.
电离辐射作为几种疾病的基本治疗方法被广泛应用。急性肾损伤（AKI）是一个全球性的公共卫生问题，具有较高的发病率和死亡率。肾缺血/再灌注（I/R）是AKI的主要原因。当肾脏的血流暂时中断然后恢复时，就会发生I/R损伤。这种缺血性损伤在短期和长期都会显著损害肾功能。肾缺血预处理（IPC）对应于旨在预防或减轻缺血性损伤的操作。在小鼠模型中，辐射诱导的预处理（IP）通过激活参与氧化应激、血管生成和炎症的防御途径，使肾实质对随后的损伤具有抗性。在设想对患者的转化应用之前，需要确定安全的辐射方式，包括时间、剂量和分割。
