Bajinka Ousman, Tan Yurong, Darboe Alansana, Ighaede-Edwards Isabella Gloria, Abdelhalim Khalid A
Department of Medical Microbiology, Xiangya School of Medicine, Central South University, Changsha, 410078, Hunan, China.
China-Africa Research Center of Infectious Diseases, School of Basic Medical Sciences, Central South University, Changsha, 410078, Hunan, China.
AMB Express. 2023 Feb 8;13(1):16. doi: 10.1186/s13568-023-01520-3.
The contribution of dysbiotic gut microbiota configuration is essential when making reference to the metabolic disorders by increasing energy. It is important to understand that the gut microbiota induced metabolic disease mechanisms and inflammations. Thus it is imperative to have an insight into the state of all chronic subclinical inflammations influencing disease outcomes. However, from the emerging studies, there still exist inconsistencies in the findings of such studies. While making the best out of the reasons for inconsistencies of the findings, this review is designed to make a clear spell out as to the inconsistence of gut microbiota with respect to diabetes. It considered gut-virome alterations and diabetes and gut-bacteriome-gut-virome-alterations and diabetes as confounding factors. The review further explained some study design strategies that will spontaneously eliminate any potential confounding factors to lead to a more evidence based diabetic-gut microbiota medicine. Lipopolysaccharide (LPS) pro-inflammatory, metabolic endotoxemia and diet/gut microbiota insulin-resistance and low-grade systemic inflammation induced by gut microbiota can trigger pro-inflammatory cytokines in insulin-resistance, consequently, leading to the diabetic condition. While diet influences the gut microbiota, the consequences are mainly the constant high levels of pro-inflammatory cytokines in the circulatory system. Of recent, dietary natural products have been shown to be anti-diabetic. The effects of resveratrol on the gut showed an improved lipid profile, anti-inflammatory properties and ameliorated the endotoxemia, tight junction and glucose intolerance.
当提及通过增加能量导致的代谢紊乱时，失调的肠道微生物群结构的作用至关重要。了解肠道微生物群诱导的代谢疾病机制和炎症很重要。因此，深入了解所有影响疾病结局的慢性亚临床炎症状态势在必行。然而，从新出现的研究来看，此类研究的结果仍存在不一致之处。在充分利用研究结果不一致的原因的同时，本综述旨在明确阐述肠道微生物群与糖尿病相关的不一致之处。它将肠道病毒组改变与糖尿病以及肠道细菌组 - 肠道病毒组改变与糖尿病视为混杂因素。该综述进一步解释了一些研究设计策略，这些策略将自发消除任何潜在的混杂因素，从而形成更具循证性的糖尿病 - 肠道微生物群医学。脂多糖（LPS）具有促炎作用，代谢性内毒素血症以及肠道微生物群诱导的饮食/肠道微生物群胰岛素抵抗和低度全身炎症可在胰岛素抵抗中触发促炎细胞因子，进而导致糖尿病状态。虽然饮食会影响肠道微生物群，但其后果主要是循环系统中促炎细胞因子持续处于高水平。最近，膳食天然产物已被证明具有抗糖尿病作用。白藜芦醇对肠道的作用表现为改善脂质谱、具有抗炎特性，并改善内毒素血症、紧密连接和葡萄糖不耐受。
