Hasegawa Hiroaki, Nango Nobuhito, Machida Masafumi
Department of Radiological Sciences, International University of Health and Welfare, Narita 286-8686, Japan.
Ratoc System Engineering Co., Ltd., Tokyo 162-0801, Japan.
Diagnostics (Basel). 2023 Mar 25;13(7):1240. doi: 10.3390/diagnostics13071240.
Quarter-detector computed tomography (QDCT) is an ultra-high-spatial-resolution imaging technique. This study aimed to verify the validity of trabecular structure evaluation using a QDCT scanner in the diagnosis of osteoporosis. We used a cancellous bone specimen image of the second lumbar vertebrae of an adult male with moderate osteoporosis. To obtain QDCT images, we created a three-dimensional model from micro-CT images of the specimen. Statistical analysis was performed on the relationship between micro-CT and QDCT imaging modalities. The differences between micro-CT and QDCT were assessed based on their significance with respect to the calculated mean measurements using the Mann-Whitney test. Single regression analysis was performed using linear regression, with micro-CT and QDCT as the explanatory and objective variables, respectively, to determine the relationship of the measured values between the two modalities. By applying the necessary correction to the micro-CT measured values, it is possible to perform an analysis equivalent to micro-CT, which offers higher spatial resolution than QDCT. We found evidence that if QDCT can be used, trabecular structure evaluation may contribute to image diagnosis to evaluate practical bone fragility.
四分之一探测器计算机断层扫描（QDCT）是一种超高空间分辨率成像技术。本研究旨在验证使用QDCT扫描仪评估小梁结构在骨质疏松症诊断中的有效性。我们使用了一名患有中度骨质疏松症的成年男性第二腰椎的松质骨标本图像。为了获得QDCT图像，我们从标本的显微CT图像创建了三维模型。对显微CT和QDCT成像方式之间的关系进行了统计分析。基于使用曼-惠特尼检验计算的平均测量值的显著性，评估了显微CT和QDCT之间的差异。使用线性回归进行单变量回归分析，分别将显微CT和QDCT作为解释变量和目标变量，以确定两种成像方式测量值之间的关系。通过对显微CT测量值进行必要的校正，可以进行与显微CT等效的分析，显微CT的空间分辨率高于QDCT。我们发现有证据表明，如果可以使用QDCT，小梁结构评估可能有助于图像诊断以评估实际的骨脆性。
