Li Jin, Zhang Xiaobin, Yang Haidong, Yang Man, Sun Hongyan
Institute of Mental Health, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, 11 Guangqian Road, Suzhou, 215137, Jiangsu, China.
Department of Psychiatry, The Fourth People's Hospital of Lianyungang, The Affiliated KangDa College of Nanjing Medical University, Lianyungang, 222003, PR China.
Schizophrenia (Heidelb). 2023 Apr 20;9(1):24. doi: 10.1038/s41537-023-00354-z.
Hippocampal abnormalities are an established finding in the neuroimaging study of schizophrenia. However, no studies have examined the possibility of regional hippocampal abnormalities specific to deficit schizophrenia (DS) and associations with the unique symptoms of this schizophrenia subtype. This study compared 33 DS and 39 non-deficit schizophrenia (NDS) patients and 38 healthy subjects for hippocampal subfield volumetry. Clinical symptoms were assessed by PANSS, cognition by the neurocognitive battery on the day of the MRI scan. The automatic hippocampal segmentation were preprocesses use FreeSurfer 7.2.0. Unfortunately, the associations between neurocognitive scores and hippocampal subfield volumes in the DS group were not significant after the Bonferroni correction. Our results did not support a causal relationship between hippocampal subregional atrophy and cognitive deficits in DS.
海马体异常是精神分裂症神经影像学研究中已确定的发现。然而，尚无研究探讨缺陷型精神分裂症（DS）特有的海马体区域异常的可能性，以及与这种精神分裂症亚型独特症状的关联。本研究比较了33名DS患者、39名非缺陷型精神分裂症（NDS）患者和38名健康受试者的海马体亚区体积。在MRI扫描当天，通过阳性和阴性症状量表（PANSS）评估临床症状，通过神经认知测试组评估认知功能。使用FreeSurfer 7.2.0对海马体进行自动分割预处理。遗憾的是，在进行Bonferroni校正后，DS组的神经认知评分与海马体亚区体积之间的关联并不显著。我们的结果不支持DS中海马体亚区萎缩与认知缺陷之间存在因果关系。
