与慢性肾脏病患者肌少症相关的因素:一项横断面单中心研究。

Factors Associated with Sarcopenia in Patients with Chronic Kidney Disease: A Cross-Sectional Single-Center Study.

机构信息

Department of Nephrology, Istanbul Training and Research Hospital, University of Health Sciences, İstanbul, Turkey.

Division of Nephrology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, İstanbul, Turkey.

出版信息

Med Sci Monit. 2023 Apr 26;29:e939457. doi: 10.12659/MSM.939457.

Abstract

BACKGROUND Sarcopenia is a recognized complication of chronic kidney disease (CKD) and increases risk of increased morbidity from cardiovascular events and mortality. This single-center cross-sectional study aimed to determine the prevalence and factors associated with sarcopenia in CKD patients. MATERIAL AND METHODS Patients with non-dialysis-dependent (NDD)-CKD were examined for sarcopenia by handgrip strength testing, bioelectrical impedance analysis (BIA), and 4-minute gait speed test. We divided 220 patients into 2 groups - No Probable Sarcopenia (NPS; n=120) and Probable Sarcopenia (PS; n=100) - according to muscle strength defined by handgrip strength, then into another 2 groups - No Sarcopenia (NS; n=189) and Confirmed Sarcopenia (CS; n=31) - according to muscle mass defined by BIA. RESULTS Mean age and prevalence of coronary heart disease were significantly higher and mean body mass index (BMI) was lower in the PS and CS groups than that of NPS and NS groups (P.

摘要

背景

肌肉减少症是慢性肾脏病(CKD)的一种公认并发症,增加了心血管事件和死亡率增加的发病率风险。这项单中心横断面研究旨在确定 CKD 患者中肌肉减少症的患病率和相关因素。

材料和方法

非透析依赖性(NDD)-CKD 患者接受握力测试、生物电阻抗分析(BIA)和 4 分钟步行速度测试,以检查是否存在肌肉减少症。我们将 220 名患者根据握力定义的肌肉力量分为 2 组 - 无肌肉减少症可能(NPS;n=120)和可能肌肉减少症(PS;n=100),然后根据 BIA 定义的肌肉量分为另外 2 组 - 无肌肉减少症(NS;n=189)和确诊肌肉减少症(CS;n=31)。

结果

与 NPS 和 NS 组相比,PS 和 CS 组的平均年龄和冠心病患病率显著较高,而平均体重指数(BMI)较低(P。

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