二酮吡咯并吡咯衍生物在癌症治疗和成像应用中的最新进展。

Recent Advances of Diketopyrrolopyrrole Derivatives in Cancer Therapy and Imaging Applications.

机构信息

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.

Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Ministry of Agriculture Key Laboratory of Animal Nutrition and Feed Science in South China, State Key Laboratory of Livestock and Poultry Breeding, Guangzhou 510641, China.

出版信息

Molecules. 2023 May 15;28(10):4097. doi: 10.3390/molecules28104097.

DOI:10.3390/molecules28104097

PMID:37241837

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10221687/

Abstract

Cancer is threatening the survival of human beings all over the world. Phototherapy (including photothermal therapy (PTT) and photodynamic therapy (PDT)) and bioimaging are important tools for imaging-mediated cancer theranostics. Diketopyrrolopyrrole (DPP) dyes have received more attention due to their high thermal and photochemical stability, efficient reactive oxygen species (ROS) generation and thermal effects, easy functionalization, and tunable photophysical properties. In this review, we outline the latest achievements of DPP derivatives in cancer therapy and imaging over the past three years. DPP-based conjugated polymers and small molecules for detection, bioimaging, PTT, photoacoustic imaging (PAI)-guided PTT, and PDT/PTT combination therapy are summarized. Their design principles and chemical structures are highlighted. The outlook, challenges, and future opportunities for the development of DPP derivatives are also presented, which will give a future perspective for cancer treatment.

摘要

癌症正在威胁着全世界人类的生存。光疗（包括光热疗法（PTT）和光动力疗法（PDT））和生物成像都是用于成像介导的癌症治疗的重要工具。二酮吡咯并吡咯（DPP）染料由于其高热和光化学稳定性、高效的活性氧（ROS）生成和热效应、易于功能化以及可调的光物理性质而受到更多关注。在这篇综述中，我们概述了过去三年中 DPP 衍生物在癌症治疗和成像方面的最新成果。总结了基于 DPP 的共轭聚合物和小分子用于检测、生物成像、PTT、光声成像（PAI）引导的 PTT 和 PDT/PTT 联合治疗。强调了它们的设计原则和化学结构。还提出了 DPP 衍生物的展望、挑战和未来发展机遇，这将为癌症治疗提供未来的视角。