Bai Long, Tao Gang, Feng Maogeng, Xie Yuping, Cai Shuyu, Peng Shuanglin, Xiao Jingang
Department of Oral Implantology, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou 646000, China.
Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Pharmaceutics. 2023 Apr 25;15(5):1334. doi: 10.3390/pharmaceutics15051334.
With the in-depth understanding of bone regeneration mechanisms and the development of bone tissue engineering, a variety of scaffold carrier materials with desirable physicochemical properties and biological functions have recently emerged in the field of bone regeneration. Hydrogels are being increasingly used in the field of bone regeneration and tissue engineering because of their biocompatibility, unique swelling properties, and relative ease of fabrication. Hydrogel drug delivery systems comprise cells, cytokines, an extracellular matrix, and small molecule nucleotides, which have different properties depending on their chemical or physical cross-linking. Additionally, hydrogels can be designed for different types of drug delivery for specific applications. In this paper, we summarize recent research in the field of bone regeneration using hydrogels as delivery carriers, detail the application of hydrogels in bone defect diseases and their mechanisms, and discuss future research directions of hydrogel drug delivery systems in bone tissue engineering.
随着对骨再生机制的深入了解以及骨组织工程的发展，近年来在骨再生领域出现了各种具有理想物理化学性质和生物学功能的支架载体材料。水凝胶因其生物相容性、独特的溶胀特性以及相对易于制备而越来越多地应用于骨再生和组织工程领域。水凝胶药物递送系统包含细胞、细胞因子、细胞外基质和小分子核苷酸，它们根据化学或物理交联方式而具有不同特性。此外，水凝胶可针对特定应用设计用于不同类型的药物递送。在本文中，我们总结了以水凝胶作为递送载体在骨再生领域的最新研究，详述了水凝胶在骨缺损疾病中的应用及其机制，并讨论了水凝胶药物递送系统在骨组织工程中的未来研究方向。
