妊娠相关自发性冠状动脉夹层:孕晚期急性冠状动脉综合征的一个罕见病因。

Pregnancy-related spontaneous coronary artery dissection: a rare cause of acute coronary syndrome in the third trimester.

机构信息

Department of Medicine, University of California, 333 The City Blvd. West, Suite 400, Orange, Irvine, CA, 92868, USA.

Department of Medicine, Division of Cardiology, University of California, Irvine, CA, USA.

出版信息

BMC Cardiovasc Disord. 2023 Jun 8;23(1):292. doi: 10.1186/s12872-023-03323-7.

Abstract

BACKGROUND

Spontaneous Coronary Artery Dissection (SCAD) is a rare cause of myocardial infarction and sudden cardiac death that is mostly seen in younger patients without significant cardiac risk factors. The mechanism by which SCAD causes an acute coronary event is related to the compromise of the coronary artery lumen as a result of hematoma within the vessel wall. In comparison to their non-pregnant counterparts, when SCAD is associated with pregnancy, it has been associated with an increased risk of life-threatening arrhythmias, cardiogenic shock, and death. The underlying mechanism behind SCAD is not yet fully understood, and despite the condition's high mortality rate, it remains underdiagnosed.

CASE PRESENTATION

Our case features a 38-year-old woman at 29 weeks of gestation presenting with chest pain that persisted despite initial management. Coronary angiography revealed a Type 2a spontaneous dissection of the left anterior descending artery. Given the risks of percutaneous coronary intervention in SCAD management and overall clinical stability, the patient was treated with conservative management.

CONCLUSION

SCADs are a rare cause of acute coronary syndrome that can be found in patients without any prior cardiac risk factors. It is important to have a high index of suspicion when diagnosing SCADs given, they can cause life-threatening arrhythmias, cardiogenic shock, and death. This case highlights considerations that must be taken into account when treating P-SCAD, as opposed to SCAD in the postpartum period.

摘要

背景

自发性冠状动脉夹层(SCAD)是一种罕见的心肌梗死和心脏性猝死的病因,多见于无明显心脏危险因素的年轻患者。SCAD 导致急性冠状动脉事件的机制与血管壁内血肿导致冠状动脉管腔受损有关。与非妊娠患者相比,当 SCAD 与妊娠相关时,其与危及生命的心律失常、心源性休克和死亡的风险增加有关。SCAD 的潜在机制尚未完全阐明,尽管该病症的死亡率很高,但仍存在漏诊。

病例介绍

我们的病例为一名 38 岁女性,妊娠 29 周,出现胸痛,尽管初始治疗后仍持续存在。冠状动脉造影显示左前降支 2a 型自发性夹层。鉴于 SCAD 管理中经皮冠状动脉介入治疗的风险以及整体临床稳定性,患者接受保守治疗。

结论

SCAD 是急性冠状动脉综合征的罕见病因,可在无任何既往心脏危险因素的患者中发现。鉴于 SCAD 可引起危及生命的心律失常、心源性休克和死亡,在诊断 SCAD 时应保持高度怀疑。该病例强调了在治疗 P-SCAD 时必须考虑的因素,与产后 SCAD 不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f28/10251557/7953fb3f90be/12872_2023_3323_Fig1_HTML.jpg

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