Shah Devanshi S, Moravkar Kailas K, Jha Durgesh K, Lonkar Vijay, Amin Purnima D, Chalikwar Shailesh S
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai, India.
Department of Industrial Pharmacy and Quality Assurance, R. C. Patel Institute of Pharmaceutical Education and Research, Karwand Naka, Shirpur, Dhule 425405, India.
Heliyon. 2023 May 24;9(6):e16498. doi: 10.1016/j.heliyon.2023.e16498. eCollection 2023 Jun.
The knowledge of powder properties has been highlighted since the 19th century since most formulations focus on solid dosage forms, and powder flow is essential for various manufacturing operations. A poor powder flow may generate problems in the manufacturing processes and cause the plant's malfunction. Hence these problems should be studied and rectified beforehand by various powder flow techniques to improve and enhance powder flowability. The powder's physical properties can be determined using compendial and non-compendial methods. The non-compendial practices generally describe the powder response under the stress and shear experienced during their processing. The primary interest of the current report is to summarize the flow problems and enlist the techniques to eliminate the issues associated with the powder's flow properties, thereby increasing plant output and minimizing the production process inconvenience with excellent efficiency. In this review, we discuss powder flow and its measurement techniques and mainly focus on various approaches to improve the cohesive powder flow property.
自19世纪以来，由于大多数制剂都集中在固体剂型上，粉末特性的知识就受到了重视，并且粉末流动性对于各种制造操作至关重要。不良的粉末流动性可能会在制造过程中产生问题并导致工厂故障。因此，应该通过各种粉末流动技术预先研究并纠正这些问题，以改善和提高粉末的流动性。粉末的物理性质可以使用药典和非药典方法来确定。非药典方法通常描述了粉末在加工过程中所经历的应力和剪切作用下的反应。本报告的主要目的是总结流动问题，并列举消除与粉末流动特性相关问题的技术，从而提高工厂产量，并以卓越的效率将生产过程中的不便降至最低。在本综述中，我们讨论了粉末流动及其测量技术，并主要关注改善粘性粉末流动特性的各种方法。
