Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Nutr. 2023 Aug;153(8):2312-2319. doi: 10.1016/j.tjnut.2023.06.033. Epub 2023 Jun 24.
There is evidence of the role of vitamin D deficiency in cognitive decline. However, the results of studies regarding the relationship between the reduction of vitamin D concentrations and cognitive impairment are heterogeneous.
We aimed to answer the question of whether vitamin D deficiency is associated with cognitive decline in older adults.
In this cross-sectional study, the baseline data of the Birjand Longitudinal Aging Study (BLAS) were analyzed. Of 1420 participants in the BLAS, 1219 participants aged ≥60 y old were included in the present study. Serum concentrations of 25-hydroxyvitamin D [25(OH)D] were measured by the enzyme-linked immunosorbent assay method. The 6-item Cognitive Impairment Test (6-CIT), Mini-Mental State Examination (MMSE), Category Fluency Test (CFT), and Abbreviated Mental Test Score (AMTS) were used to assess cognitive function. Multiple logistic regression analysis, adjusted for potential confounders, was employed to estimate the association between cognitive function and 25(OH)D concentrations.
Among study participants, 905 (74.24%) had sufficient vitamin D concentrations (≥20 ng/ml), 209 (17.15%) had insufficient vitamin D concentrations (12-20 ng/ml), and 105 (8.61%) had vitamin D deficiency (<12 ng/ml). There was no significant correlation between serum 25(OH)D concentrations and scores of 6-CIT (P = 0.279), AMTS (P = 0.181), MMSE (P = 0.118), and CFT (P = 0.259). Also, the prevalence of cognitive impairment had no significant relationship with vitamin D status. Finally, in the multiple logistic regression analysis, there was no association between the insufficient or deficient concentrations of 25(OH)D and impaired cognitive function both before and after adjustment for various cofounders.
The present study found no significant association between vitamin D status and cognitive impairment.
有证据表明维生素 D 缺乏与认知能力下降有关。然而，关于维生素 D 浓度降低与认知障碍之间关系的研究结果存在差异。
我们旨在回答维生素 D 缺乏是否与老年人认知能力下降有关的问题。
本研究为横断面研究，分析了比詹德纵向老龄化研究（BLAS）的基线数据。在 BLAS 的 1420 名参与者中，纳入了本研究的 1219 名年龄≥60 岁的参与者。采用酶联免疫吸附试验法检测血清 25-羟维生素 D [25(OH)D]浓度。采用 6 项认知障碍测试（6-CIT）、简易精神状态检查（MMSE）、类别流畅性测试（CFT）和简短精神状态评分（AMTS）评估认知功能。采用多因素 logistic 回归分析，调整潜在混杂因素后，估计认知功能与 25(OH)D 浓度之间的关系。
在研究参与者中，905 名（74.24%）有足够的维生素 D 浓度（≥20ng/ml），209 名（17.15%）有不足的维生素 D 浓度（12-20ng/ml），105 名（8.61%）有维生素 D 缺乏症（＜12ng/ml）。血清 25(OH)D 浓度与 6-CIT 评分（P=0.279）、AMTS 评分（P=0.181）、MMSE 评分（P=0.118）和 CFT 评分（P=0.259）之间无显著相关性。此外，认知障碍的患病率与维生素 D 状态也无显著关系。最后，在多因素 logistic 回归分析中，在校正了各种混杂因素后，25(OH)D 浓度不足或缺乏与认知功能受损之间无关联。
本研究未发现维生素 D 状态与认知障碍之间存在显著关联。
