Department of Research and Development, Chlorella Industry Co., Ltd., Hisatomi 1343, Chikugo 833-0056, Fukuoka, Japan.
Research Center for Innovative Cancer Therapy, Kurume University, Kurume 830-0011, Fukuoka, Japan.
Nutrients. 2023 Jun 30;15(13):2995. doi: 10.3390/nu15132995.
Methylsulfonylmethane (MSM) is a food ingredient present in small amounts in many foods, and its anti-inflammatory effects have been reported. We conducted a randomized, double-blind, placebo-controlled trial of oral consumption of MSM on mild pain of the knee joint in healthy Japanese participants. A total of 88 participants were enrolled in this study and randomly assigned to MSM consumption ( = 44) and placebo control ( = 44) groups. Both groups of participants took 10 tablets, each containing 200 mg MSM or lactose, per day for 12 weeks. The primary outcome of this study was measured values of the total score of the Japanese Knee Osteoarthritis Measure (JKOM) at 12 weeks after the test sample consumption. Safety evaluation was performed through physical examination, urine analysis, peripheral blood test, and medical interview. The total scores at 12 weeks in the MSM and placebo groups as the primary outcome were significantly different ( = 0.046). The health condition of JKOM also improved after MSM consumption ( = 0.032). The questionnaire results also suggested improvement in the knee and systemic health. This study indicated that MSM oral consumption improved both knee and systemic health conditions in healthy participants who experienced mild pain in the knee joint.
甲磺酰甲烷（MSM）是一种存在于许多食物中的食品成分，其具有抗炎作用。我们进行了一项随机、双盲、安慰剂对照试验，研究了口服 MSM 对健康日本参与者膝关节轻度疼痛的影响。共有 88 名参与者被纳入本研究，并随机分为 MSM 组（n=44）和安慰剂对照组（n=44）。两组参与者每天各服用 10 片，每片含 200mg MSM 或乳糖，持续 12 周。本研究的主要结局是在试验样品摄入后 12 周时日本膝关节骨关节炎测量量表（JKOM）总分的测量值。通过体检、尿液分析、外周血检查和医疗访谈进行安全性评估。作为主要结局的 12 周时 MSM 和安慰剂组的总分差异有统计学意义（ = 0.046）。MSM 摄入后，JKOM 的健康状况也得到改善（ = 0.032）。问卷调查结果还表明，膝关节和全身健康状况有所改善。本研究表明，MSM 口服摄入可改善膝关节轻度疼痛的健康参与者的膝关节和全身健康状况。
